摘要
目的探讨全球急性冠状动脉事件注册（GRACE）风险评分及外周血红细胞分布宽度（RDW）与冠状动脉病变严重程度的关系。方法选择2011年6月～2013年12月河北省秦皇岛市第二医院拟诊为冠心病、心肌梗死等疾病而行冠状动脉造影的患者218例为研究对象，对所有患者进行GRACE风险评分及RDW测定。根据RACE危险评分将其分为低危（GRACE〈90分）、中危（90～133分）、高危三组（〉133分）。结果132例患者有不同程度的冠状动脉病变，86例患者为非冠状动脉病变者。冠状动脉病变者RDW值为（14．11±1．27）％，非冠状动脉病变者RDW值为（12．82±1．56）％，两者比较差异有高度统计学意义（P〈0．01）。GRACE风险评分越高，冠状动脉病变血管支数越多，其中高危组3支血管病变率（32．6％）显著高于中危组（24．2％）和低危组（9．4％），差异均有统计学意义（均P〈0．05）。同时，GRACE风险评分越高，血管狭窄程度也越严重，其中高危组血管重度狭窄率（32．6％）显著高于中危组（24．2％）和低危组（5．7％），两两比较差异均有统计学意义（均P〈0．05）。低危组、中危组、高危组RDW值分别为（13．38±1．79）％、（13．88±1．61）％和（14．21±1．98）％，三组两两比较差异均有统计学意义（均P〈0．05）。结论GRACE风险评分及RDW与冠状动脉病变严重程度密切相关，两者可为冠状动脉病变患者风险评估及个体化治疗提供依据。
Objective To investigate the relationship between GRACE risk scoring, peripheral blood red cell distribu- tion width （RDW） and the severity of coronary artery disease. Methods 218 patients with suspected coronary heart dis- ease or myocardial infarction to receive coronary artery angiography from June 2011 to December 2013 in the Second Hospital of Qinhuangdao City, all patients were given the GRACE risk scoring and RDW determination, all the patients were divided into low risk group （GRACE〈90 scores）, intermediate risk group （90-133 scores） and high risk group （〉 133 scores） according to the RACE risk score. Results 132 patients had different degree of coronary artery lesion, 86 cases without coronary artery disease. RDW of patients with coronary artery lesion was （14.11±1.27）%, and the RDW of patients without coronary artery lesion was （12.82±1.56）%, the difference was highly statistically significant （P 〈 0.01）. The higher the GRACE risk scores, the more pathological blood vessels, the incidence of 3 vessel in the high risk group （32.6%） was higher than that of the middle risk group （24.2%） and the iow risk group （9.4%）, the differences were sta- tistically significant （all P 〈 0.05）. At the same time, the higher the GRACE risk scores, the more serious of the steno- sis degree, the high-risk group of vascular stenosis rate （32.6%） was significantly higher than that of the middle risk group （24.2%） and the low risk group （5.7%）, the differences were statistically significant （all P 〈 0.05）. RDW value of the low risk group, medium risk group, high risk group were （13.38±1.79）%, （13.88±1.61）%, （14.21±1.98）% respectively, the differences were statistically significant （all P 〈 0.05）. Conclusion The GRACE risk score and RDW is closely related to the severity of coronary artery disease, which can provide the basis for the risk assessment of coronary artery disease and individualized treatment.
出处
《中国医药导报》
CAS
2014年第16期146-148,共3页
China Medical Herald
基金
河北省秦皇岛市科学技术研究与发展计划(第二批)项目(编号2012023A065)
