摘要
目的探讨卵巢子宫内膜异位囊肿、子宫内膜异位症相关的卵巢癌(卵巢子宫内膜样癌和卵巢透明细胞癌)中抑癌基因PTEN蛋白和凋亡抑制基因Survivin蛋白表达及意义。方法利用免疫组织化学二步抗法检测卵巢子宫内膜异位囊肿20例、子宫内膜异位症相关的卵巢癌17例,正常子宫内膜20例中PTEN蛋白、Survivin蛋白的表达。结果 PTEN蛋白在正常子宫内膜的阳性表达低于子宫内膜异位症相关的卵巢癌、卵巢子宫内膜异位囊肿,差异具有统计学意义(P<0.05)。Survivin蛋白的趋势与PTEN相反,差异具有统计学意义(P<0.05)。PTEN、Survivin蛋白表达与分期、分化程度,差异无统计学意义(P>0.05)。PTEN、Survivin蛋白表达无明显相关性(r=0.143,P>0.05)。结论卵巢子宫内膜异位囊肿发生恶变的过程中可能与PTEN、Survivin蛋白表达异常有关,可能PTEN蛋白表达异常更有意义。
Objective To investigate the expression of PTEN protein and Survivin protein in endometriosis associated ovarian cancers（EAOCs） and their significance and correlation. MethodsImmunohistochemical method was used to detect the expression of PTEN and Survivin in 17 cases of EAOCs, 20 cases of endometrial cyst of the ovary and 20 cases of normal endometrium. Results The positive rates of PTEN immunostaining showed higher expression in normal endometrium than the others. Respectively, there were significant difference between the three groups（P〈0.05）. The tendency of Survivin expression was opposite to that of PTEN. The positive expression of PTEN and Survivin was not correlated with clinical stage and differentiation degree of cancer cells（P〉0.05）. The positive expression of PTEN was not correlated with Survivin. ConclusionPTEN and Survivin protein may be associated between endometrial cyst of the ovary and ovarian cancer associatedto endometriosis, and PTEN protein is more significant.
出处
《中国实用医药》
2014年第15期3-6,共4页
China Practical Medicine
