摘要
目的：探讨静脉应用胺碘酮治疗老年急性心肌梗死并室性心律失常的临床疗效及安全性。方法：选择110例急性心肌梗死并室性心律失常的老年患者,对照组（54例）用利多卡因50-100 mg静脉注射,后1-4 mg/min静脉维持；治疗组（56例）采用胺碘酮150-300 mg静脉注射,然后0.5-1.5 mg/min静脉维持；治疗24 h后观察2组24 h内的疗效、室性心律失常次数、PR间期、QRS波时限、校正的QT间期及不良反应。结果：治疗组总有效率94.64%高于对照组的83.33%（P〈0.05）；室性心律失常发生次数低于对照组（P〈0.01）,QRS波时限较对照组短,PR间期比对照组长,校正的QT间期较对照组轻度延长（P〈0.01）；2组不良反应差异无统计学意义（P〉0.05）。结论：静脉应用胺碘酮治疗老年急性心肌梗死并室性心律失常疗效肯定,未增加不良反应,可作为治疗老年急性心肌梗死并室性心律失常的首选药物。
Objective：To investigate the curative effects and safety of amiodarone in the treatment of acute myocardial infarction elderly patients complicated with ventricular arrhythmia. Methods：One hundred and ten acute myocardial infarction elderly patients complicated with ventricular arrhythmia were divided into treatment group and control group. The treatment group（56 cases）and control group（54 cases） were treated with 150 to 300 mg of amiodarone by intravenous injection,then intravenous drip with 0. 5 to 1. 5 mg/min and 50 to 100 mg of lidocaine by intravenous injection, then intravenous drip with 1 to 4 mg/min, respectively. The number of ventricular arrhythmia,PR interval, QRS wave time, correct QT and adverse reactions in two groups were observed at 24 hours after treatment. Results：The total effective rate of the treatment group（94. 64%） was higher than that of the control group（83. 33%）（P〈0.05）.Thenumberof ventricular arrhythmia in treatment group was less than that in control group（P〈0.01）.Compared with the control group,the short correct QT wave time, long PR interval and QTc were found in treatment group. The difference of adverse reaction between two groups had no statistical significance（P〉0. 05）. Conclusions：The effects of amiodarone in the treatment of acute myocardial infarction elderly patients complicated with ventricular arrhythmia are good,and no obvious added side effects are found. Amiodarone can be used as a preferred drug in treating acute myocardial infarction elderly patients complicated with ventricular arrhythmia.
出处
《蚌埠医学院学报》
CAS
2014年第6期721-723,共3页
Journal of Bengbu Medical College
基金
蚌埠医学院科研计划项目(BY1037)
关键词
心肌梗死
心律失常
胺碘酮
myocardial infarction
ventricular arrhythmia
amiodarone
