摘要
目的探讨降纤酶联用依达拉奉治疗急性脑梗死的疗效。方法 96例急性脑梗死患者随机分为治疗组(50例)、对照组(46例),2组均给予常规治疗,对照组应用依达拉奉,治疗组应用降纤酶联用依达拉奉治疗,比较2组患者治疗后其血浆纤维蛋白原水平及治疗效果。结果治疗组治疗后72 h、治疗后2周其血浆纤维蛋白原水平与对照组相比具差异有显著性(P<0.05),治疗组治疗前与治疗后72 h血浆纤维蛋白原水平相比差异有统计学意义,治疗组总有效率高于对照组,二者比较差异有显著性(P<0.05)。结论降纤酶联合依达拉奉较单用依达拉奉可增加急性脑梗死患者脑血液灌注,改善脑微循环,有助于患者的神经功能康复。
Objective To explore the curative effect of defibrase coupled with edaravone for the treatment of acute cerebral infarction.Methods 96 cases of patients with acute cerebral infarction were divided randomly into a treatment group （50 ca-ses） and a control group （46 cases）.Edaravone was applied to the control group but for the treatment group defibrase com -bined with edaravone was administered .Both groups were treated in conventional way .After the treatment , plasma fibrinogen levels and therapeutic effect of the two groups were compared .Results Compared to the control group ,the treatment group had lower level of plasma fibrinogen （P〈0.05） 72h and 2w after the treatment and manifested significant difference before and 72h after the treatment in terms of plasma fibrinogen levels .For the treatment group ,the average therapeutic effect was bet-ter than the control group （P〈0.05）.Conclusion Compared to using edaravone alone , defibrase coupled with edaravone can increase the cerebral blood perfusion ,improve the brain microcirculation and contribute to neural functional recovery of the patients with acute cerebral infarction .
出处
《淮海医药》
CAS
2014年第4期351-352,共2页
Journal of Huaihai Medicine
关键词
脑梗死
降纤酶
依达拉奉
治疗结果
Cerebral infarction
Defibrase
Edaravone
Treatment outcome
