摘要
目的 通过观察高胰岛素型高血压病人服用小剂量螺内酯前后血压、空腹血胰岛素浓度、空腹血糖、空腹血总胆固醇等的变化 ,观察其疗效。方法 采用双盲法将高胰岛素型高血压病人 162例随机分组 ,分别服用小剂量螺内酯 (A组 ,83例 )及安慰剂 (B组 ,79例 ) ,疗程 8周 ,测量并比较以上数据变化。结果 治疗组空腹血糖、血总胆固醇与对照组比较无明显变化 ,舒张压与收缩压明显下降 (P <0 .0 5 ) ,空腹血胰岛素浓度明显下降 (P <0 .0 5 )。结论 小剂量螺内酯在不干扰体内脂质、糖等代谢的情况下能有效改善胰岛素抵抗型高血压病人血压 ,同时还能明显降低体内空腹胰岛素浓度。
Objective To evaluate the efficacy of small dose of spironolactone in treatment of hypertention with high insulin through observing the change of hollow blood pressure,blood insulin level,blood glucose and blood cholesterol.Methods We divide 162 patients into two groups randomly.83 patients take small dosage of spironolactone,and the others take placebo.After 8 weeks of treatment,we measure and compare the data in them.Results We find that the hollow blood glucose and cholesterol of the patients who take small dose of spironolactone don't change obviously while the systolic and dystolic blood pressure decline obviously(P<0.05),and so does the hollow blood insulin level(P<0.05).Conclusion Small dose of spironolactone can reduce not only blood pressure but also insulin level obviously without disturbing metablism of glucose and cholesterol.
出处
《河北医药》
CAS
2001年第3期171-172,共2页
Hebei Medical Journal
