摘要
目的探讨分析HBsAg阳性肝硬化患者血小板数及其他参数与肝组织纤维增生的关系。方法分别选择乙肝组58例,、肝硬化组109例,以及对照组60例。采用全自动血常规分析仪Sysmex XE-2100检测血小板计数(PLT)以及其他参数:平均血小板体积(MPV)、血小板分布宽度(PDW)。结果肝硬化组PLT数([89.9±43.5)×109/L]明显低于乙肝组([115±59)×109/L]和健康对照组([176±55)×109/L(]P<0.01)。在肝硬化组内,PLT数随着肝组织纤维化程度增加呈明显下降,S1-S4期分别为:(166.2±31.9)×109/L,(147.4±34.0)×109/L,(113.8±30.4)×109/L,(89.9±19.0)×109/L,差异有统计学意义(P<0.01),MPV随着肝组织纤维化程度增加呈明显增大,S1-S4期分别为(9.1±1.3),(9.4±0.8),(9.8±0.9),(10.1±0.8)(,P<0.05),PDW只有S4与S3之间有统计学意义(P<0.05)。结论PLT计数及其参数MPV、PDW值对评估HBsAg阳性肝硬化的严重程度有重要意义,可为乙肝病毒性肝炎所致肝硬化的临床防治提供指导。
Objective To analyze correlation of the levels of platelet and parameters in liver cirrhosis patients with the severity of hepatic fibrosis. Methods Fifty-eight hepatitis B cases aged 19-68 years（hepatitis B group）, 109 cirrhosis eases aged 21-72 years （cirrhosis group） and 60 health control aged 23-65 years （control group） were selected and the levels of platelet and other parameters of PDW and MPV in the cases of three groups were determined with assistance of automatic hematocyte analyzer （Sysmex XE,2100）. Results The number of PLT in cirrhosis group was [（89.9 ±43.5）×10^9/L], significantly lower than that [（115±59）×10^9/L] in Hepatitis B group and [（ 176±55 ）×10^9/L] in healthy control group （P〈0.05）. The number of platelet decreased along with progress of liver cirrhosis （P〈0.05）. The platelet levels at staging IS1）, staging II （SII）,staging III（SIII） and staging IV （SIV） were as the follows：（166.2±31.9）×10^9/L, （147.4±34.0）×10^9/L, （113.8±30.4）×10^9/L, （89.9±19.0） ×10^9/L, showing significant difference （P〈0.01）. The MPV was enlarged with the progress of severity of hepatic fibrosis. While PDW showed significant difference at SI （9.1 ±1.3, 9.4±0.8） and SIV staging, （9.8-＋0.9, 10.1 ±0.8）（P〈0.05）. Conclusion The count of platelet, PDW and MPV are important reference and valuable for assessment of liver function and severity in liver cirrhosis patients.
出处
《中国热带医学》
CAS
2014年第6期723-724,727,共3页
China Tropical Medicine
关键词
乙型肝炎
肝硬化
血小板
Hepatitis B
Liver cirrhosis
Platelets
