摘要
目的：运用Meta分析研究GNB3基因C825T位点多态性与勃起功能障碍的相关性。方法检索Pubmed、Medline、中国期刊网全文数据库（CNKI）、万方数据库和维普中文科技期刊库，按照纳入标准纳入文献，对文献进行资料提取后，运用STATA 12.0软件进行Meta分析。结果共纳入4篇研究，包括969例ED患者和795例对照。采用共显性模型进行Meta分析，结果显示CC基因型较TT基因型与勃起功能障碍发病无显著关联（OR=0.639，95%CI：0.386-1.059，P =0.083）；对不同人群进行亚组分析提示亚组人群CC基因型较TT基因型勃起功能障碍患病风险增加；欧洲人群GNB3基因C825T位点基因多态性与勃起功能障碍无明显关联（CC vs TT， OR=1.043，95%CI：0.602-1.810，P=0.88； CT vs TT，OR=0.989，95%CI：0.568-1.723，P=0.97）。结论亚洲人群GNB3基因CC基因型为勃起功能障碍的危险因素，而在欧洲人群中关联尚不明确。
Objective To investigate the association of GNB3 C825T polymorphism with erectile dysfunction. Methods The related literatures were extracted from the database of PubMed, Medline, CNKI, VIP and Wanfang according to the inclusion criteria. A meta-analysis was done using STATA 12.0 software. Results All of 969 patients and 795 controls in the extracted four published studies were analyzed by codominant genetic model. The results showed that GNB3 C825T polymorphism had no significant association with the risk of erectile dysfunction in the general population（OR=0.639, 95%CI： 0.386-1.059, P=0.083）; Subgroup analysis indicated that CC genotype was significantly associated with erectile dysfunction in the Asian population（OR=0.431, 95%CI：0.290-0.642, P =0.00）. However, there was no significant association in the European population（CC vs TT, OR=1.043, 95%CI： 0.602-1.810, P=0.88; CT vs TT, OR=0.989, 95%CI：0.568-1.723,P=0.97）. Conclusion The CC genotype is a risk factor of erectile dysfunction in the Asian population, but not in the European population.
出处
《中国男科学杂志》
CAS
CSCD
北大核心
2014年第5期11-14,共4页
Chinese Journal of Andrology
基金
国家自然科学基金（81170563）
