摘要
目的制备并优化芷芎散鼻用温敏凝胶的处方,并考察其体外释放机制和鼻黏膜渗透特性。方法利用星点设计-效应面法优化泊洛沙姆温敏凝胶基质处方,然后经Franz扩散池法考察欧前胡素、阿魏酸的体外释放机制及其离体家兔鼻黏膜渗透特性。结果最优处方为泊洛沙姆407(P407)20%、泊洛沙姆188(P188)6.5%,欧前胡素接近零级释放模型,阿魏酸接近Higuchi模型,处方对欧前胡素和阿魏酸的透过鼻黏膜均具有促进作用。结论优化所得的处方为芷芎散新给药途径制剂的开发提供基础。
Objective To prepare and optimize the formulation of intranasal thermo-sensitive gel of Zhi Xiong San and to evaluate its in vitro release mechanism and nasal mucosa permeability.Methods The formulations of poloxamer thermo-sensitive gel were optimized by a central composite design-response surface method and its in vitro release mechanism and nasal mucosa permeability were evaluated by Franz diffusion chambers.Results The optimal formulation was Poloxamer 407（P407） 20% and Poloxamer 188（P188） 6.5%.Imperatorin was released from the thermo-sensitive gels approximately with a zero-order mechanism,while ferulic acid with a Higuchi model.The formulation demonstrated the enhancement of nasal mucosa permeability.Conclusion The optimal formulation provides a basis for the development of new administration routes and dosage forms of Zhi Xiong San.
出处
《中草药》
CAS
CSCD
北大核心
2014年第13期1845-1849,共5页
Chinese Traditional and Herbal Drugs
基金
广东省科技计划项目(2010B030700009024)
关键词
白芷
川芎
泊洛沙姆
温敏凝胶
体外释放
鼻黏膜渗透性
Angelicae Dahuricae Radix
Chuanxiong Rhizoma
Poloxamer
thermo-sensitive gel
in vitro release
nasal mucosal permeability
