摘要
目的 :观察冠心病 (CHD)患者血清肿瘤坏死因子 (TNF)、白细胞介素 - 6 (IL- 6 )的变化与临床意义。方法 :采用放射免疫分析法 (RIA)测定 45例 CHD患者及 30例健康者 (对照组 )血清 TNF,IL- 6水平。结果 :CHD患者血清TNF,IL- 6水平均显著高于对照组 (P<0 .0 1) ,尤以心肌梗死患者为明显 (P<0 .0 1) ;心肌梗死组血清 TNF,IL- 6水平较心肌缺血组显著升高 (P<0 .0 1) ;急性心肌梗死患者血清 TNF,IL- 6水平高于陈旧性心肌梗死患者 (P<0 .0 5 ) ;心肌缺血组心功能 ～ 级患者血清 TNF,IL- 6水平较心功能 ～ 级患者升高显著 (P<0 .0 1) ;血清TNF水平与 IL- 6之间呈明显正相关 (r=0 .73,P<0 .0 1)。结论 :血清 TNF,IL- 6水平与 CHD病情严重程度密切相关 ,TNF,IL- 6可能参与 CHD的发生与发展。
AIM:To study the changes of serum tumor necrosis factor(TNF) and interleukin 6 (IL 6) in patients with coronary heart disease (CHD) and their clinical significance. METHODS:The serum TNF and IL 6 in 45 patients with CHD and in 30 healthy controls were determined by using radioimmunoassay (RIA). RESULTS:The serum TNF and IL 6 levels in patients with CHD were markedly higher than those in the controls ( P <0.01),and especially those in patients with myocardial infarction were more obvious ( P <0.01). The serum TNF and IL 6 levels in myocardial infarction were much higher than those in myocardial ischemia ( P <0.01). In patients with myocardial infarction,the serum TNF and IL 6 levels in AMI patients were higher than those in OMI patients ( P <0.05). In myocardial ischemia patients,the serum TNF and IL 6 level at heart function stages Ⅲ~Ⅳ, were higher than those at heart function stages Ⅰ~Ⅱ ( P <0.01). The serum TNF level was obvious positively correlated with IL 6 ( r =0.73, P <0.01). CONCLUSION:The levels of serum TNf and IL 6 are closely related to the severity of CHD. The study has implied that TNF and IL 6 may contribute to the formation and progression of CHD.
出处
《心脏杂志》
CAS
2001年第3期173-174,共2页
Chinese Heart Journal
