摘要
本文观察了大鼠20％体表面积Ⅲ°烧伤后,补给不同剂量的维生素E(V_E)对血清、肝脏V_E,血清过氧化脂质(LPO)水平及实验14天后胸腺和脾脏变化情况。结果表明:烧伤后摄入正常需要量的V_E不能满足机体的需要,血清V_E水平下降,LPO水平升高,胸腺萎缩,脾脏肿大;伤后补V_E 1mg或2mg/100g体重,可使血清V_E水平升高,LPO水平升高幅度,胸腺和脾脏变化减小,肝中V_E贮存量显著升高,后一剂量效果更好;补充V_E 5或10mg/100g体重时,肝中V_E含量分别为正常组的6至10倍,血清LPO水平大为降低,几乎为正常组的一半,而胸腺萎缩和脾脏肿大加剧。认为烧伤后每天补给V_E的适宜剂景为2mg/100g体重,即正常需要量的10倍为宜。
The effects of supplementation of vitamin E ( VE ) on serum and liver VE and serum lipid peroxides ( LPO ) levels were studied in 20% BSA Ⅲ° turned rats. The relation between amount supplemented and weight of thymus and spleen were also investigated on the 14th postburn day.The result showed that serum and liver VE contents decreased, serum LPO increased, thymus was atrophic, and spleen was swollen in the rat ( burned group Ⅰ) received VE 0.2mg/100g bw/d per os as compared with the uninjured control received same dosage of VE. Average serum and liver VE level rose significantly in burned group Ⅱ and Ⅲ rats received VE 1mg and 2mg/100g bw/d respectively. And 7 days poslinjuved, no significant difference was found between serum LPO level of these two groups and of unburned control group. There was no significant difference between weight changes in thymus and spleen of burned group Ⅲ and control either. Protection of VE on thymus and spleen injury in group Ⅳ and group Ⅴ ( received VE 5 or 10mg/100g bw/d respectively ) was worse than that in group Ⅲ ( received VE 2mg/100g bw/d ) . Thus it suggested that supplemented of VE for burned rats was about 2mg/100g bw/d.
出处
《基础医学与临床》
CSCD
1991年第5期42-45,共4页
Basic and Clinical Medicine
