摘要
目的 探讨服用 1 3 1 I后合并内科药物治疗甲亢对 1 3 1 I疗效的影响。方法 将 187例 Graves'病甲亢患者随机分为两组 ,第一组 93例 ,接受 1 3 1 I治疗 ;第二组 94例 ,1 3 1 I治疗后 3天加用丙基硫氧嘧啶 (PTU ) 5 0 mg tid治疗 1个月。治疗后每周测定患者的 FT3 、FT4、T3 、T4以及 TSH水平 ,6个月后评价 1 3 1 I的疗效。结果 在治疗后 6个月 ,两组患者中分别有 2 2例 (2 3.6% )及 18例 (19.1% )仍处于甲亢 ,有 8例 (8.6% )及 7例 (7.4% )发生甲低 ,有63例 (67.8% )及 69例 (73.4% )患者甲状腺功能维持正常。总的治愈率分别为 76.3% (71例 )及 80 .5 % (76例 )。两组疗效比较无显著性差异 (χ2 =0 .176,P>0 .5 0 )。结论 服用 1 3 1 I后合并 PTU治疗不会影响 1 3 1
Objective To ascertain whether the therapoutic effect of 131 I is affected by the additional use of thyrostatic medication.Methods One hundred and eighty seven patients with Graves' disease (GD) were randomly assigned to treatment with 131 I alone or plus thyrostatic medication(PTU) 3 days after the beginning of 131 I therapy. All patients were examined every month for six months after treatment. Results The cure of hyperthyroidism occurred in 71 of 93 patients(76.3%) treated with 131 I alone and in 76 of 94 patients(80.5%) treated with 131 I plus thyrostatic medication(PTU). There were no significant differences in cure rate between the two groups. Conclusion The additional use of thyrostatic medication 3 days after the beginning of 131 I therapy will not affect the efficacy of 131 I in the treatment of GD
出处
《华西医科大学学报》
CSCD
北大核心
2001年第3期449-451,共3页
Journal of West China University of Medical Sciences
