摘要
本文探讨了锌、镍煤尘的联合作用。实验指标有肺泡巨噬细胞(AM)内ATP、K^+和Zn^(2+)测定以及细胞表面扫描电镜观察。结果提示低锌对镍煤尘的AM毒作用起保护作用,这一作用与其剂量有关。AMK^+含量、ATP水平是反映细胞毒性的敏感指标可用于检测环境毒物。
In present paper, the possibility of the antagonistic effects of zinc on the nickel coal dust had been explored. The parameters in this set ofexperiments were cellular ATP level in AM, cellular K^+ and Zn^(2+) in AM,and the surface morphological changes of AM. The results of these studiesshowed that low zinc can antagonize the toxicity of nickel coal dust onAM. The antagonistic effects of zinc on the toxicity of nickel coal dustdepend on the dosage. The ATP level and K^+ content in AM are sen-sitive indices in reflecting the cytotoxicity. These indices can be used indetecting environmental toxic substances.
出处
《解放军预防医学杂志》
CAS
北大核心
1991年第5期344-347,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
锌
镍煤尘
AM
ATP
K^+
扫描电镜
Zinc
Nickel Coal Dust
AM
ATP
K^+
Scanning Electron Microscope
