摘要
目的 :研究痢疾杆菌的耐药性及多重耐药性细菌性痢疾的抗生素治疗。方法 :对患者进行便培养及药敏检查 ,应用氨基糖甙类、喹诺酮类、第三代头孢菌素类、利福平等抗菌药物及联合用药。结果 :证实本地区急性细菌性痢疾的病原体仍以福氏志贺菌为主 ,该菌对氨苄青霉素、复方新诺明、痢特灵耐药率在 80 %以上 ,对头孢曲松钠未见耐药性。136例急性细菌性痢疾经不同药物治疗 ,头孢曲松钠组、氧氟沙星组及丁胺卡那霉素加利福平组均有较高治愈率。头孢哌酮组及庆大霉素加诺氟沙星组治愈率较低 ,与上述各组比较均有显著性差异 ( P<0 .0 5 )。结论 :通过对志贺菌属耐药性研究表明 ,应及时选用无耐药性或耐药性较低的抗菌药物 ,第三代喹诺酮 (氧氟沙星 )及第三代头孢菌素 (头孢曲松钠 )类为首选药物。
Objective:It is to study drug tolerance of Bacillus dysenteriae and antibiotic treatment on multiple drug tolerance bacillary dysentery.Methods:Bacterium cultivation experiment of feces and antibiotic susceptibility test were dad to patients.Aminoglycosides,quinolones,third generation cephalosporins,rifampin etc.and combined modality were used. Results: The pathogen of acute bacillary dysentery was mostly Shigella flexneri in local area.Its drug tolerance rate was more than 80% to ampicillin,sulfamethoxazole and furazolidone,but was zero to ceftriaxone sodium.After 136 patients with bacillary dysentery treated with different drug,the cure rates were high in ceftriaxone sodium group,ofloxacin group and kanamycin sulfate add to rifampin group ,and it was low in cefoperazone group and gentamicin sulfate add to norfloxacin group.Conclusion:Through drug tolerance of shigella being studied,it was proved that antibiotic with no tolerance or low tolerance should be chosen to use in time,and third quinolones(ofloxacin) and third generation cephalosporins(ceftriaxone sodium)should be used firstly in treatment.;
出处
《现代中西医结合杂志》
CAS
2001年第17期1611-1613,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
细菌性痢疾
痢疾志贺菌
多种耐药性
抗生素
治疗
bacillary dysentery Bacillus dysenteriae multiple drug tolerance antibiotic
