摘要
目的:探讨四逆汤对大鼠心力衰竭的防治机理。方法:实验大鼠随机分为正常对照组、单纯心衰组、心衰加四逆汤大剂量组、心衰加四逆汤中剂量组、心衰加四逆汤小剂量组、心衰加地高辛组、心衰加附子组、心衰加干姜组、心衰加甘草组,共9组。除正常对照组外,其余各组用盐酸阿霉素尾静脉注射造模,1次/5天,共3次。注药完毕后开始药物灌胃,3周后进行心功能测定(心输出量、左心室最大变化速率)。结果:四逆汤随着剂量的加大,其保护心衰心肌的作用增强,与地高辛比较无明显差异。而拆方研究发现,防治心衰作用则全方大于单味药。结论:四逆汤具有防治大鼠心力衰竭的作用。
Objective:To explore the effect of Sini Tang(ST) on rats with heart failure.Methods: The experimental rats were allocated randomly to 9 groups, i.e.,control group,simple heart heartre (HF)group,HP plus large dosage of ST group,HF plus moderate dosage of ST group,HF plus small dosage of ST group,HF plus digoxin group,HF plus Radix Aconiti Lateralis Preparata group,HF plus Rhizoma Zingiberis group,and HF plus Radix Glycyrrhizae group.Besides the control group all other groups were modelled by injection of adriamycin hydrochloride to the caudal vein once every 5 days for three times.After the injections were finished,drugs were perfused intragastrically for 3 weeks ,then the cardiac function (including cardiac output and the maximal change speed of left ventricle) was estimated.Results:The protective effect of ST for the failing cardiac muscle increased with its dosage and showed no marked difference as compared with digoxin.Study of individual ingredients showed that the action of whole prescription is stronger than that of individual drug .Conclusion:ST possesses preventive and therapeutic effect in HF in rats.
出处
《新中医》
CAS
北大核心
2001年第11期75-77,共3页
New Chinese Medicine
基金
广东省中医药管理局课题(编号:99559)
广东省自然科学基金课题(编号:001323)
关键词
四逆汤
药理学
血液动力学
充血性心力衰竭
实验研究
Sini Tang :pharmacology
hemodynamics
heart failure
congestive
diseased model, animal
rat
