摘要
目的 监测军队人群流感抗体水平 ,获知易感人群的比例 ,了解流感毒株的变异趋势。 方法 2 0 0 0年春 ,在全军 8个监测地区 ,采集 711例军人血清 ,应用 9种国内及国际流感病毒代表株以微量半加敏血凝抑制方法进行抗体检测。 结果 军队人群中 ,甲 3型流感病毒抗体阳性率 78 0 4%～ 94 0 1% ,抗体平均滴度 (GMT)最高达 82 ,易感人群占 5 99%～ 2 1 96%。对 4种不同甲 1型毒株抗体水平之间存在很大差异 ,依次为 83 3 4 %、63 96%、48 71%、2 3 2 9%呈梯度下降 ,GMT :61、40、3 7、2 4。易感人群依次升高为 16 66%、3 6 0 4%、5 1 2 9%、76 71%。对乙型流感的感染率分别为 5 8 90 %、47 95 % ,GMT :3 4、2 7。易感人群 41 10 %、5 2 0 5 %。西藏地区人群对甲 3型、B型流感染率比其他地区普遍偏低 (P <0 0 1;P >0 0 1) ,对近期的甲 3型代表株A/沪防 /1/98(H 3N2 )感染率为 5 0 % ,GMT :2 5。对两个B型株感染率分别为 2 0 %、12 % ,GMT :2 1、10。 结论 除西藏地区外 ,部队人群中对甲 3亚型株抗体阳性率以达饱和水平。 提示 甲 3型流感可能在近几年内发生较大变异。甲 1亚型毒株几乎每年都有变异。军队人群对A/京防 /5 3 /97抗体阳性率很低 ,因此该亚型有可能在军营中引起流行。乙型流感因易?
Objective To survey the antibody level of influenza in the Army population,so as to obtain the ratio of susceptible and to find out the varietion range and epidemic trend of influenza virus. Methods The sera of 711 soldiers were collected in the Spring of 2000,and the influenza antibodies were detected by using minimum half sensitizing haemoglutinin inhibition assay with 9 strains of national and international influenza viruses. Results The study showed that the level of A3 antibody was high in the Army.The antibody positive rates (AbPRs) were 78.04%～ 94.01% ,and the antibody geometric mean (GMT) was even up to 82.The susceptible population were 5.99%～ 21.96% .The antibody levels of 4A1 types were greatly different.They were 83.34%、63 96%、48 71% and 23.29% respectively.And GMT were:61、40、37 and 24.The AbPRs of influenza B were 58.90% and 47.95% respectively.GMT were:34 and 27.The susceptible crowd were 41.10% and 52.05%.The level of influenza antibody was declined obviously in the Tibetan population. Conclusion The level of crowd antibody against A3,except Tibetan population has been satiated.Therefore the antigen might be mutations.H1N1 strain would cause a local outbreak.The susceptible population influenza B was half.The influenza B was possibly in local prevalence as well.The antibody level of influenza was lower in the Tibetan crowd.Thus it would be very important to forecast and predict the epidemic trend of influenza.
出处
《实用预防医学》
CAS
2001年第4期241-243,共3页
Practical Preventive Medicine
基金
总后勤部"九五"课题资助项目 (95 -A0 1 1 )
