摘要
目的探讨葛根素注射液对原发性高血压病患者血浆一氧化氮 (NO)、内皮素 (ET)的影响。方法用硝苯吡啶及疏甲丙脯酸 (西药组 )与葛根素注射液 (200～ 400 mg)配合硝苯吡啶和疏甲丙脯酸 (中西药结合组 )分别治疗原发性高血压患者各 30例，观察 2组患者的血压、 NO和 ET的变化。结果西药组治疗前后收缩压分别为 (22. 51± 2. 14)kpa(1 kpa=7. 5 mmHg)与 19. 62± 1. 93)kpa(P<0. 001)，舒张压分别为 (13. 26± 1. 34)KPa与 (11. 84± 1. 49)KPa(P<0. 001)； NO分别为 (4. 10± 0. 99)μ mol/L与 (4. 97± 0. 95)μ mol/L(P<0. 01)； ET分别为 (90. 30± 12. 90)ng/L与 (67. 50± 10. 76)ng/L(P<0. 001)。中西药结合组治疗前后收缩压分别为 (22. 52± 2. 31)kpa与 (20. 46± 1. 91)kpa(P<0. 001)；舒张压分别为 (13. 22± 1. 03)kpa与 (11. 75± 1. 37)kpa； NO分别为 (4. 04± 1. 22)μ mol/L与 (5. 07± 1. 03)μ mol/L(P<0. 01)； ET分别为 (88. 90± 11. 23)ng/L与 (55. 70± 8. 05)ng/L(P<0. 001)。治疗前 2组血压、 NO、 ET处于同一水平 (P>0. 05)，治疗后以中西药结合组改善更为明显 (与治疗后西药组比较，血压： P<0. 001， ET， NO∶ P均 <0. 001)。结论葛根素注射液可通过改善血循环状态对
Objective:To explore the effect of puerarin injection on Plasma endothelin (ET) and Nitric Oxide (NO) in Patients with essential hypertension.Methods:Thirty cases of essential hypertension were treated with nifedipin and captopril(Western medicine group),in addition,30 cases were treated with puerarin injection(200～ 400mg)combined use of nifedipin and captopril.Integrated teaditional Chinese and Western medicine growp,ITCWMgroup,then to observe the therapeutic effect of 2 groups (include blood pressure,NO and ET levels).Results:In the western medicine group,systolic pressure were(22. 51± 2. 14)KPa(1 KPa=7. 5 mmHg) and 19. 62± 1. 93)KPa before and after treatment respectively (P < 0. 001);diastolic pressures were (13. 26± 1. 34)KPa与 (11. 84± 1. 49)KPa respectively (P < 0. 001)； NO levels were (4. 10± 0. 99)μ mol/L and (4. 97± 0. 95)μ mol/L respectively (P < 0. 01)； ET levels were (90. 30± 12. 90)ng/L and (67. 50± 10. 76)ng/L respectively (P < 0. 001)。 However,in the ITCWM group,systolic pressures were (22. 52± 2. 31)KPa and (20. 46± 1. 91)KPa before and after treatment respectively (P < 0. 001)； diastolic pressures were (13. 22± 1. 03)KPa and (11. 75± 1. 37)KPa respectively (P < 0. 0001)； NO levels were (4. 04± 1. 22)μ mol/L and (5. 07± 1. 03)μ mol/Lrespectively (P < 0. 01)； ET levels were (88. 90± 11. 23)ng/L and (55. 70± 8. 05)ng/L respectively (P < 0. 001);it ranged in same level of blood pressure,NO and ETlevel between 2 groups (all P > 0. 05) before treatment,but affer treatment the improvenent extent in ITCWM group was superior to western medicine group (blood pressure:P < 0. 001， ETandNO∶ both P < 0. 001).Conclusion:Puerarin can accommodate imbalance of NO、 ET metabolism through improving blood circulation and protecting structure and function of VEC in hypertensives,So it is benefit for decreasng blood pressure through regulating vaso－ constrictive and vaso－ dilative function.
出处
《井冈山医专学报》
2001年第3期10-11,共2页
Journal of Jinggangshan Medical College
