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粘蛋白MUC_1与卵巢肿瘤研究进展 被引量：1

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摘要 MUC1粘蛋白是一种分布于人上皮细胞表面高度糖化、高分子量的糖蛋白 ,在卵巢肿瘤细胞其表达水平上调 ,糖基化发生改变 ,从而影响肿瘤细胞的粘附力、免疫识别、转移 ,与卵巢肿瘤的发生。
作者 王莉莉
机构地区 西安中医医院妇产科
出处 《国外医学（妇幼保健分册）》 2001年第4期152-154,共3页 Foreign Medical Sciences (Section of Maternal and Child Health)
关键词 MUC1粘蛋白 卵巢肿瘤 预后 结构 生物学行为
分类号 R737.31 [医药卫生—肿瘤]
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参考文献12

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  • 3Rachel JQ,Michae AM. Phosphorlation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion[J]. Int J Cancer,2000,87:499-506.
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  • 5Cao Y, Blohm D, Ghadimi BM,et al. Mucins(MUC1and MUC3) of gastrointestinal and breast epithelia reveal different and heterogeneous tumor-associated aberrations in glycosylation[J]. J Histochem cytochem, 1997, 45:1547-1557.
  • 6Kondo K, Kohno N,Yokoyama A,et al. Decreased MUC1 expression induces E-cadherin - midiated cell adhesion of breast cancer cell lines[J]. Cancer Research, 1998,58: 2014-2019.
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  • 8Chan AK,Lockhart DC,Von BW, et al.Soluble MUC1 secreted by human epithelial cancer cells mediates immune suppression by blocking T- cell activation[J]. Int J Cancer, 1999,82:721-726.
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同被引文献20

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  • 5Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis : a potential mechanism of immune evasion[J]. Nat Med, 2002,8 (8) : 793.
  • 6Jodo S,Kobayashi S,Nakajima Y,et al. Elevated serum levels of soluble Fas/APO-1 (CD95) in patients with hepatocellular carcinoma[J]. Clin Exp Immunol, 1998,112(2) : 166.
  • 7Kareela PI ,Green SJ ,Bowden SJ ,et al. Identification of a binding site for intergrin alpha E beta(7) in the N-terminal domain of Ecadherin[J] .J Biol Chem, 1996,271(48):30909.
  • 8Ishigami S, Natsugoe S, Tokuda K, et al. CD3-zetachain expression of intratumoral lymphocytes is closely related to survival in gastric caxcinoma patients[J]. Cancer,2002,94(5) : 1437.
  • 9Santin AD,Hermonat PL,Ravaggi A, et al. Phenotypic and functional analysis of tumor-infiltrating lymphocytes compared with tumor-associated lymphocytes from ascitic fluid and peripheral blood lymphocytes in patients with advanced ovarian cancer [J].Gynecol Obstet Invest,2001,51(4) :254.
  • 10Hu HM, Urba WJ, Fox BA. Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell from a type 2 to a type 1 cytokine profile [J]. Journal of Immunology, 1998, 161( 6 ):3033.

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国外医学（妇幼保健分册）
2001年 第4期

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