摘要
目的 :用大鼠牙龈炎动物模型对牙龈炎症程度的评定指标进行研究。方法 :采用丝线缝扎大鼠牙颈部 ,辅以高糖饮食造成牙龈炎动物模型 ,7天后测定牙龈局部血流及龈沟液天冬氨酸转氨酶 (AST)含量的变化。结果 :模型动物牙龈充血红肿有溃疡和浅牙周袋形成。牙龈炎局部血流量和血流速度有一定程度的增加 ,且血细胞数升高更加显著 (P <0 0 5 ) ,龈沟液AST较对照组有所升高经统计学分析 ,有显著性差异。 (P <0 0 0 1)。结论 :该模型为良好的牙龈炎动物模型 ,龈沟液AST及局部微血流的改变均是反映牙龈炎发病程度的客观评定指标。
Objective:To study the experimental gingivitis animal model and the indication of inflammation level.Methods:The gingivitis animal model was made by suturing the neck of rat teeth and fed high sugar.Local blood flow and crevicular fluid aspartate aminotransferase levels were measured on the 7th day after operation.Results:The local gingiva became red and swelling and superficial periodontal pocket formed after operation.The quantity and velocity of local blood flow increases to some extent in model group,cell number in blood flow increased significantly (P<0.05).The crevicular fluid aspartate aminotransferase levels increased very significantly (P<0.001) compared with control group.Conclusion:Objective evaluation from local blood flow and crevicular fluid aspartate aminotransferase levels indicates that a reasonable gingivitis animal model has been established.
出处
《北京口腔医学》
CAS
2001年第4期170-171,共2页
Beijing Journal of Stomatology
关键词
牙龈炎
动物模型
局部血流
龈沟液天冬氨酸转氨酶
gingivitis animal model local blood flow crevicular fluid aspartate aminotransferase
