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肝移植术后巨细胞病毒感染 被引量:7

Cytomeglovirus infection after liver transplantation
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摘要 目的 探讨肝移植术后巨细胞病毒感染的诊断和防治方法。 方法 回顾分析 10例肝移植患者临床资料 ,并结合文献进行讨论。 结果 共有 6例患者发生巨细胞病毒感染 ,6例均为无临床症状的巨细胞病毒感染 ,其中 5例治愈。 结论 荧光探针定量基因检测技术是诊断巨细胞病毒感染的一种快速、敏感性和特异性很高的方法。重视术前、术后巨细胞病毒感染的监测、积极预防及早期治疗是关键。更昔洛韦能有效治疗巨细胞病毒感染。 Objective To study the prophylaxis, diagnosis and treatment of cytomegalovirus (CMV) infection after liver transplantation. Methods The clinical data of 10 patients receiving liver transplantation from July 1999 to October 2000 in our hospital were retrospectively analyzed along with literature review. Results CMV infection occurred asymptomatic cally in 6 patients, of whom, 5 were cured. Conclusions Fluorogenic quantitative PCR (FQ PCR) is effective, sensitive and highly specific for detecting CMV infection. It is important to monitor the status of CMV infection in patients receiving liver transplantation preoperatively and postoperatively. The key point for prophylaxis and treatment of CMV infection is early prevention and treatment after operation. Ganciclovir can exert significant therapeutic effects on CMV infection.
出处 《中华外科杂志》 CAS CSCD 北大核心 2001年第9期684-685,共2页 Chinese Journal of Surgery
关键词 肝移植 巨细胞病毒感染 荧光探针定量基因检测技术 Liver transplantation Cytomegalovirus infection
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参考文献5

  • 1Patel R,Snydman DR,Rubin RH,et al.Cytomegalovirus prophylaxis in solid organ transplant recipients[].Transplantation.1996
  • 2Paya CV,Wiesner RH,Hermans PE,et al.Risk factors for cytomegalovirus and severe bacterial infections following liver trensplantation[].Hepatology.1993
  • 3Winston DJ,Wirin D,Shaked A,et al.Randomised comparison of ganciclovir and high-dose acyclovir for long term cytomegalovirus prophylaxis in liver-transplant recipients[].The Lancet.1995
  • 4Badley AD,Seaberg EC,Porayko MK,et al.Prophylaxis of cytomegalovirus infection in liver transplantations[].Transplantation.1997
  • 5Colonna JO,Winston DJ,Brill JE,et al.Infection complication in liver transplantation[].Archives of Surgery.1988

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