摘要
目的 :了解国内随机对照试验Meta分析的质量 ,找出问题所在 ,提高研究质量。资料与方法 :以检索到的 6个国内随机对照试验的Meta分析报告为研究样本 ,以Sacks等提出的Meta分析质量评价方法为基础 ,对评分细则稍加调整 ,作为评价标准。评价标准包含 6个方面的 2 3个项目。根据每个项目是否被涉及和规范程度 ,酌情计予 4、2或 0分。每个研究的 2 3个项目的总分除以满分 (92分 ) ,得到一个质量百分数。结果 :6项研究的平均得分为 (4 0 .94± 2 0 .92 ) ,最高得分为 71.74,最低为 17.39,这些研究的得分差距非常大。对在此次质量评价中考虑的 6个方面的所有 2 3个项目 ,只有一项Meta分析强调了 6个方面的至少 1个项目 ;2项Meta分析强调了 5个方面的至少 1个项目 ;一项Meta分析强调了 4个方面的至少 1个项目 ;1项Meta分析强调了 3个方面的至少 1个项目 ;Meta分析只强调了 2个方面的至少 1个项目。对所有 2 3个项目 ,只有 4～ 17个项目被强调。结论 :急需对Meta分析方法的应用加以规范 ,既推广 ,又防止“
Objective: To evaluate the quality of meta-analysis for internal randomized controlled trials, identify the problems, raise the quality of study. Materials and Method: Six meta-analysis reports of internal randomized controlled trials obtained by exploration were served as samples, the quality evaluation method for meta-analysis posed by Sacks et al was served as a foundation, the detail giving a mark was served as a evaluating standard. The 23 items in six respects was included into the evaluating standard. Four, two or zero mark was given on the basis of circumstances according to the extent of standard. The sum of point of each study was divided by the full mark(92 marks), a quality percentage was obtained. Results: The obtained average mark of six studies was 40.94(n=20.92), the highest mark was 71.74, the lowest was 17.39, the gap of mark obtained by the studies was very significant. All the 23 items of six respects considered in this quality evaluation, at least one tiem of six respects was emphasized only in one meta-analysis; at least one item of five respects was emphasized by two meta-analysis; at least one item of four respects was emphasized by one meta-analysis; at least one item of three respects was emphasized by one meta-analysis; at least one item of two respects was emphasized by one meta-analysis. Only 4-17 items were emphasized in all 23 items. Conclusion: It is badly in need of application of meta-analysis to be standard, not only should be papularized, and abuse should be prevented also.
出处
《药物流行病学杂志》
CAS
2002年第1期31-36,共6页
Chinese Journal of Pharmacoepidemiology
