摘要
本文通过Ti-5Al-2.5Fe、Ti-6Al-4V和纯钒的体外实验以及前两者的体内实验评价了Ti-5Al-2.5Fe的生物相容性。细胞培养结果表明Ti-5Al-2.5Fe对二种细胞形态、乳酸脱氢酶(LDH)、巨噬细胞葡萄糖-6-磷酸脱氢酶(G-6-PD)和吞噬功能无明显影响。Ti-6Al-4V对巨噬细胞亚微结构线粒体有一定影响,并使G-6-PD和吞噬功能明显降低。纯钒使巨噬细胞溶解死亡。动物体内植入结果表明二种钛合金膜厚在三个月时已达美国材料测试学会(ASTM-Fe)的标准。六个月Ti-5Al-2.5Fe膜厚明显小于Ti-6Al-4V。实验结果表明纯钒有强细胞毒作用。新型钛合金Ti-5Al-2.5Fe具有良好的体内外生物相容性,是更理想的外科植入材料。
A new titanium alloy Ti-5A1-2. 5Feis developed based on Ti-6A1-4V.Both mouse peritoneal macrophagesand HeLa cells appeared to be unaf-fected by Ti-5Al-2. 5Fe assessed bymorphological changes, release oflactate dehydrogenase (LDH), theactivity of glucose-6-phosphate de-hydrogenase (G-6-PD) of macropha-ges and phagocytosis. Ti-6Al-4Vdecreased both G-6-PD activity andphagocytic capacity significantly(P<0. 01). Pure vanadium destroy-ed macrophages in a short time.104 implants of Ti-5Al-2. 5Fe or Ti-6Al--5V in 52 rabbits after 1/2 to 6months were studied to observe thethickness of the capsule and cellularinteraction. It demonstrated that thecapsule of Ti-5Al-2. 5Fe group rea-ched criteria given by The AmericanSociety for testing materials(ASTM-F_4) three months after-implantation. The thickness of capsulewas significant difference (P<0.01)from that of Ti-6Al-4V at the endof six month implantation. Inflamma-tory leukocytes were rarely seen atthe end of six month implantation.Combined the results in vitro and invivo, the present study demonstratesthat Ti-5Al-2. 5Fe would be a moreideal material for implantation invivo.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1991年第1期19-26,共8页
Journal of Biomedical Engineering
关键词
生物相容性
生物植物
钛合金
Biocompatibility
Biomaterials
Cell culture
Titanium alloy
