摘要
目的 对1 3 1 I和抗甲状腺药物 (ATD)治疗甲状腺功能亢进症 (甲亢 )进行综合评价 ,定量评价两种方法的优劣。方法 甲亢治愈为 0分 ,好转为 1分 ,无效为 2分 ;治疗后出现突眼或突眼加重、甲亢性心脏病 (甲心病 )、肝功能受损、血象降低者为 2分 ;出现暂时性甲状腺功能减退症 (甲低 )者为 1分 ,永久性甲低者为 2分 ;甲亢治愈后复发者为 2分 ;将各项得分和总分进行比较。结果 1 3 1 I治疗组 2 30例总得分 319分 ,平均得分 1.39,ATD治疗组 2 5 0例总得分 5 6 9分 ,平均得分 2 .2 0 ,两者差异有显著性 (t=6 .982 ,P <0 .0 0 1) ;1 3 1 I疗效优于ATD ;发生突眼方面两者无差别 ,但ATD对突眼的改善优于1 3 1 I;1 3 1 I治疗后甲低的发生率高于ATD (χ2 =5 5 .6 5 ,P =0 .0 0 1) ;甲亢治愈后复发明显低于ATD治疗 ,出现甲亢性心脏病、血象、肝功能受损等方面低于ATD (χ2 =39.5 0 ,P <0 .0 0 1)。结论 1 3 1 I治疗甲亢疗效优于ATD治疗 ,尽管有甲低、突眼等发生 ,但甲亢复发及出现其他系统损伤较ATD治疗少。
Objective To comprehensively mark the treatment of hyperthyroidism with 131 I and antithyroid drugs(ATD) and to quantitatively assess the advantages and the disadvantages of them. Methods In two therapeutic methods of hyperthyroidism those being cured were marked 0,those getting better were marked 1,those remaining unchanged were marked 2. After treatment the patients demonstrated ophthalmopathy or more severe ophthalmopathy,hyperthyroid heart disease, liver function damage and leukopenia were marked 2,those showed temporary hypothyroidism and permanent hypothyroidism were marked 1,2,respectively.Those who had a relapse of the disease after being cured were marked 2.Both individual kinds of marks and total marks were compared. Results The total mark of group treated with 131 I was 319,and the average mark was 1.39;the total mark of group treated with ATD was 569,and the average mark was 2.20,the difference between the two groups was significant ( P <0.001).The incidences of ophthalmopathy of the two groups were not significantly different,but in improving ophthalmopathy the ATD excelled 131 I( P <0.05).The patients treated with 131 I contracted hypothyroidism more often than those treated with ATD( P =0.001).The patients cured with 131 I their hyperthyroidism relapse obviously less occurred than in those cured with ATD.In the patients treated with 131 I the incidences of hyperthyroid heart disease, liver function damage, leukopenia and so on were less than in those treated with ATD( P <0.001). Conclusions 131 I therapy excels the ATD in treatment of the patients with hyperthyroidism. Although there is certain incidence of hypothyroidism, ophthalmopathy and so on after 131 I treatment, its total curative effect is better than that of ATD.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2002年第1期31-32,共2页
Chinese Journal of Nuclear Medicine
