摘要
目的 研究高原低氧环境对大鼠学习记忆的影响。方法 利用新生大鼠低氧模型和胎鼠低氧模型 ,采用爬杆实验和Morris水迷宫实验进行检测。结果 爬杆实验中习得的速度减慢 ,消退速度加快。Morris水迷宫实验中逃避潜伏期延长 ,撤除平台后跨越平台次数减少。结论 高原低氧环境下大鼠的学习记忆能力受到抑制 。
Objective To study the effect of hypobaric hypoxia on learning and memory.Method Newborn and fetus hypobaric hypoxia rats were used on the pole-jump test and Morris water maze.Result In pole-jump test, the speed of acquisition slowed in the newborn and fetus hypobaric hypoxia. In the Morris water maze, latency to find a hidden platform was longer and the frequency of pass through the platform was decreased.Conclusion The result suggest hypobaric hypoxia may inhibited learning and memory via decrease NMDA receptor of hippocampus.
出处
《中国行为医学科学》
CSCD
2002年第1期8-9,共2页
Chinese Journal of Behavioral Medical Science
基金
全军九五医药卫生基金资助 ( 98M0 89)
