摘要
目的 观察扩张型心肌病 (DCM )患者血清中组织纤维化指标的变化 ,以期探讨心肌纤维化的DCM病程中的临床意义。方法 以放免法测定DCM患者 4 5例 ,分别于心力衰竭和病情控制后 ,以及正常对照组 30例血清中透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )和层粘连蛋白 (Laminin ,LN)的浓度 ,并将上述各参数作相关分析。结果 DCM患者血清中HA、PCⅢ、LN水平分别为 (130 .12± 32 .72 ) μg/L、(183.99± 36 .79) μg/L、(196 .72±39.6 3) μg/L ,较正常对照组水平显著增高 ,而且心力衰竭发作 [分别为 (338.37± 30 .74 ) μg/L、(2 81.39± 37.38)μg/L、(2 92 .93± 38.72 ) μg/L]时更为显著。 结论 血清HA、PCⅢ、LN可作为DCM患者心肌纤维化的血清学指标 。
Objective To investigate the changes of serum fibrotic markers in dilated cardiomyopathy (DCM) patients and to discuss their clinic significance. Methods Serum hyaluronic acid (HA), procollagen Ⅲ(PCⅢ) and Laminin(LN) were measured by radioimmunoassay in 45 patients with DCM during heart failure and after control, and 30 healthy subjects. The results were analyzed. Result The concentration of serum HA, PC Ⅲ and LN in DCM patients were (130.12±32.72)μg/L, (183.99±36.79)μg/L, (196.72±39.63)μg/L respectively, and were significantly increased than in normal group. Their concentration were significantly increased in the group of heart failure [(338.37±30.74)μg/L, (281.39±37.38)μg/L, (292.93±38.72)μg/L)]. Conclusion These findings suggest that measurement of serum HA, PC Ⅲ and LN may provide indirect diagnostic information on myocardial fibrosis and status associated with DCM.
出处
《上海医学检验杂志》
北大核心
2002年第2期77-78,共2页
Shanghai Journal of Medical Laboratory Sciences
