摘要
目的 探讨缬沙坦对高血压患者血管内皮功能及胰岛素抵抗的影响。方法 32例原发性高血压患者口服缬沙坦治疗 10周前后 ,采静脉血测定空腹胰岛素及空腹血糖 ,然后计算胰岛素敏感性指数 ;采用高分辨率血管外超声法检测治疗前后肱动脉内皮依赖性血管舒张功能。结果 缬沙坦治疗 10周后病人的收缩压和舒张压均降低 ,分别为(15 0 .6± 4 .6vs 12 5 .6± 10DBP :94 .6± 14 .2vs 80 2± 6 .7,P <0 0 5 ;空腹胰岛素水平较前降低及胰岛素敏感指数均较前显著升高 ,分别为 15 .6 4± 3.2 4vs 10 4± 0 5 4和 - 4 .36± 0 4 0vs - 3.82± 0 35 ,P <0 0 5。肱动脉内径的基础值及血流介导的内皮依赖性舒张功能明显改善 ,分别为 3.75± 0 6 3mmvs 4 .2 1± 0 4 2mm和 4 .4 0± 0 2 3mmvs 8.5 4± 0 5 5mm ,P <0 0 5。结论 缬沙坦能有效降压和改善胰岛素抵抗及肱动脉内皮依赖性舒张功能。
Aim To investigate the effects of Valsartan on endothelium dependent vasodilation and insulin resistance in hypertnsive patients. Methods Fasting blood glucose and insulin were measured in 32 patients with hypertension before and after 10 weeks treatment with valsartan. Endothelial function was assessed in the brachial artery by high resolution ultrasound technique before and after the treatment.\ Result After 10 weeks valsartan SBP and DBP wase decreased(SBP:150 6±4.6 mmHg vs 125.6±10 mmHg, DBP: 94.6±14.2 mmHg vs 80 2±6.7 mmHg P <0 05). Fast insulin was reduced and insulin sensitive index was increased significantly(15.6±3.2 vs 10 4± 0 5 and -4.36±0 40 vs -3.82± 0 35 P <0 05).\ Basic diameter and flow mediated endothelium dependent vasodilation of brachial artery was improved(3.75±0 63 mm vs 4.21±0 42 mm and 4.40±0 23 mm vs 8.54±0 55 mm, P <0 05). Conclsions Valsartan can effectively decrease blood pressure and improve endothelium dependent vasodilation in brachial artery and insulin resistance.
出处
《高血压杂志》
CSCD
2002年第1期47-48,共2页
Chinese Journal of Hypertension
