摘要
CpG诱发免疫反应的能力对免疫预防是一大优点 ,但在基因治疗中 ,质粒中所含的CpG基元能够阻止基因转移或导致巨大副作用 (炎症和毒性 )。本文简单综述了CpG基元的免疫学活性、主要作用和信号转导通路 。
Though the ability of CpG motifs to trigger an immune response represents a great advantage for vaccination,CpG motifs contained in plasmids can prervent gene transfer or lead to dramatic side effects (inflammation and toxicity).We summarize the immunological activity,main function and signal transduction pathway of CpG motifs and provide the discussion of the problems of CpG motifs in gene therapy and the possible solution. ;
出处
《生物工程进展》
CSCD
2002年第1期22-24,共3页
Progress in Biotechnology
关键词
CPG基元
免疫学活性
信号转导通路
基因治疗
CpG motif,immunological activity,signal transduction pathway,gene therapy
