摘要
目的 通过静脉推注一定剂量的关附甲素治疗阵发性室上速以了解关附甲素对阵发性室上速治疗的效果并初步探讨其可能的作用机制。方法 对随机入选的 33例阵发性室上速患者 ,在其心动过速发作时按4mg/kg的剂量静脉推注关附甲素 ,观察并记录用药前后心电图各间期 (如PR、RR、RP’、P’R和QT间期、P波及QRS时限 )的变化以及对病人血压的影响 ,通过食道心电图了解其终止心动过速的作用部位。结果 (1)关附甲素对血压无影响 ,不使已有的低血压加重 (P >0 0 5 )。 (2 )关附甲素可延长P波时限和PR间期 (P <0 0 5 ) ,而对QRS波时限和QTc间期无影响 (P >0 0 5 )。 (3)关附甲素治疗室上速的总有效率为 5 8 8% ,在房室折返性心动过速中 ,对旁道具有选择性的阻断作用。 (4 )关附甲素的平均起搏时间为 (4 0 4± 1 80 )min。结论 关附甲素能有效终止阵发性室上性心动过速 ,起效快 ,副作用少 。
Objective\ To investigate the efficacy of Guan-fu base A (GFA) in the treatment of patients with paroxysmal supraventricular tachycardia (PSVT) and the possible mechanism.Methods\ 33 patients with PSVT were randomized to receive GFA,these patients were administrated with GFA in dose of 4mg/kg during the period of tachycardia.We observed the changes of electrocardiogram(ie.PR?RR?RP'?P'R and QT interval,and the duration of QRS) and of blood pressure before and after therapy,and to acknowledge the effetive sites of GFA.Results\ We found that GFA had no effect on blood pressure and could not accentuate hypotension.Although GFA has no change in the duration of QRS and QTc interval(P>0 05),but it could prolong the duration of P wave and PR interval (P<0 05).The overall effective rate of GFA was 58 8% in the treatment of patients with PSVT,the average therapeutic time was(4 04±1 8)mins.We also found that GFA had an selective block effect in accessory pathway.Conclusion\ GFA can effectively terminate PSVT,and has the advantage of less side effects and rapid action.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2002年第4期212-213,共2页
Chinese Journal of Practical Internal Medicine
