摘要
目的:探讨半夏泻心汤加减浓煎剂治疗食管贲门癌术后反流性食管炎的疗效。方法:纳入60例食管贲门癌术后并发反流性食管炎患者,采用随机数字表法分为治疗组和对照组,每组各30例。对照组患者给予奥美拉唑、多潘立酮片口服,治疗组患者给予半夏泻心汤加减浓煎剂加奥美拉唑、多潘立酮片口服,治疗周期为8周。比较两组患者的胃镜下黏膜分级改善疗效、主要症状积分及患者的满意度。结果:治疗后,治疗组胃镜下黏膜分级改善疗效总有效率为93.33%,对照组为70.00%,治疗组的疗效优于对照组(P<0.05)。治疗后,治疗组患者的症状积分较治疗前明显降低(P<0.01),对照组患者的症状积分与治疗前比较差异无统计学意义(P>0.05),且治疗组患者的症状积分显著低于对照组(P<0.01)。治疗后,治疗组患者的满意度为90.00%,对照组为66.67%,治疗组患者的满意度优于对照组(P<0.05)。结论:半夏泻心汤加减浓煎剂联合奥美拉唑、多潘立酮可有效改善食管贲门癌术后并发反流性食管炎患者的临床症状和胃镜下的黏膜损伤,提高患者的满意度。
Objective: To investigate the efficacy of concentrated decoction of modified Banxia Xiexin Decoction in the treatment of reflux esophagitis after esophagus and cardia cancer operation. Methods: Sixty patients with reflux esophagitis after resection of esophageal and cardiac carcinoma were selected and randomly divided into the treatment group and the control group according to random number table,30 cases in each group. The patients in the control group were orally treated with omeprazole and domperidone tablet and the patients in the treatment group were orally treated with concentrated decoction of modified Banxia Xiexin Decoction plus omeprazole and domperidone tablet,with a course of 8 weeks. The improvement efficacy of mucosa grade by gastroscope,the main symptoms score and the patients’ satisfaction degree in both groups were compared. Results: After treatment,the total effective rates on the improvement efficacy of mucosa grade by gastroscope in the treatment group and the control group were 93.33% and 70.00% respectively,and the efficacy of the treatment group was better than that of the control group( P<0.05). After treatment,the symptoms score of the treatment group was significantly decreased compared with treatment before( P<0.01),but there was no statistically significant difference on the symptoms score between treatment before and after in the control group( P>0.05),and the symptoms score of the treatment group was significantly lower than that of the control group( P<0.01). After treatment,the satisfaction degrees of the treatment group and the control group were90.00% and 66.67% respectively,and the satisfaction degree of the treatment group was better than that of the control group( P<0.05).Conclusion: The concentrated decoction of modified Banxia Xiexin Decoction combined with omeprazole and domperidone can effectively improve the clinical symptoms and gastroscopic mucosal damage in patients with reflux esophagitis after esophageal and cardiac cancer operation,and enhance the satisfaction of patients.
作者
赵鑫
陆晔
ZHAO Xin;LU Ye(Graduate School,Nanjing University of Chinese Medicine,Nanjing 210000,China;Second Affiliated Hospital of Nanjing University of Chinese Medicine,Second Traditional Chinese Medicine Hospital of Jiangsu Province,Nanjing 210017,China)
出处
《上海中医药大学学报》
CAS
2018年第6期15-18,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
江苏省中医药管理局科技项目(YB2017036)
关键词
半夏泻心汤
浓煎剂
食管贲门癌
术后
反流性食管炎
Banxia Xiexin Decoction
concentrated decoction
esophagus and cardia cancer
postoperation
reflux esophagitis
