摘要
目的探讨保温救生衣对低温海水浸泡犬的保护作用。方法将10只中华田园犬随机分成两组。实验组穿上自行研发的保温救生衣,对照组穿上普通救生衣。两组动物置于11. 00±0. 24℃的海水中,于浸泡前、浸泡后在海水中观察两组动物的生存情况、肛门温度、平均动脉压、心率及呼吸,并检测凝血指标及血浆乳酸(LAC)。待动物死亡时,取其重要器官(肝脏、心脏、肺等)做HE染色病理切片分析。结果实验组动物生存时间均超过4h,对照组动物4h内病死率为100%。实验组有更加显著的保温效果,其浸泡后3h的肛门温度、平均动脉压、心率、呼吸及纤维蛋白原(FIB)均高于对照组(P <0. 05),凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)及血浆乳酸水平(LAC)均显著低于对照组(P <0. 05),重要器官(肝脏、心脏、肺、腹直肌组织)病理炎性反应指标明显低于对照组。结论保温救生衣能有效改善落水者的低体温现象,明显降低病死率,对维持生命的延续具有重大意义。
Objective To determine protective effect of heat preservation life jacket on low temperature seawater immersion dogs. Methods Ten healthy chinese countryside dogs were randomly divided into two groups.The dogs in experimental group had been put on self-developed heat preservation life jacket,while dogs in control group had been put on ordinary life jacket.Both groups animals were placed in the water of 11.00±0.24 degrees celsius.In sea water,the survival rate,anal temperature,mean arterial pressure,heart rate, respiration were observed and coagulation index and plasma lactic acid (LAC)were measured before and after sea water immersion in both groups.When all the animals died,the pathological changes in the vital organs (liver,heart,lungs,etc.)were observed by means of HE staining.Results In the experimental group,all animals survived more than 4 hours,while the mortality rate of control group was 100% within 4 hours.And the experimental group had a more significant effect of heat preservation.3 hours after seawater immersion,the levels of anal temperature,mean arterial pressure,heart rate,respiration and fibrinogen(FIB)were higher significantly in experimental groupthan that in control group(P <0.05),while the levels of prethrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),blood lactate (LAC)were lower significantly in experimental groupthan that in control group (P <0.05).The inflammatory indexes of the vital organs (liver,heart,lung,rectus abdominis muscle)were significantly better in experimental group than those in the control group.Conclusion The heat preservation life jacket can effectively raise the body temperature of the drowning dog,and significantly reduce mortality,which is the great significance of continue life.
作者
林楠
蔡志聪
吴伟航
杨为锦
洪杰
林丽
林志雄
林晨
王瑜
陈东生
Lin Nan;Cai Zhicong;Wu Weihang(Fuzhou General Hospital of the Chinese People's Liberation Army &Clinical Institute of Fuzhou General Hospital,Fujian Medical University,Fujian 350025,China)
出处
《医学研究杂志》
2018年第11期92-95,共4页
Journal of Medical Research
基金
中国人民解放军南京军区重大科研项目(15DX024)
福建省科技厅社会发展引导性(重点)项目(2016Y0072)
中国人民解放军神州总医院军事医学研究专项基金资助项目(2016J02)
关键词
低体温
保温救生衣
海水浸泡
Hypothermia
Heat preservation life jacket
Seawater immersion
