摘要
阿尔茨海默病(Alzheimer Disease,AD)是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变,病理变化主要包括老年斑沉积和神经原纤维缠结。自噬(autophagy)是细胞内受损细胞器和聚集蛋白质的主要降解途径。生理条件下,细胞内新成分的产生和异常沉积的蛋白质或受损细胞器的清除处于动态平衡状态,这种平衡一旦被打破,机体就会受到不同程度的损伤。自噬在AD中具有重要作用,自噬机制障碍可能导致神经系统异常蛋白沉积。本文就近几年有关自噬和AD的相关研究进行详细系统的综述。
Alzheimer’s Disease(AD) is a central nervous system degenerative disorder characterized by progressive cognitive dysfunction and behavioral impairment,and pathological changes mainly include senile plaque deposition and neurofibrillary tangles. Autophagy is the primary degradation pathway for aggregated proteins and damaged organelles in the cells. Under physiological conditions, the generation of new ingredients in the cell and the removal of abnormal deposition of proteins or the damaged organelles are in a state of dynamic balance,and the body suffers varying degrees of damage once this balance is broken. Autophagy plays an important role in AD, and disorders of autophagy may lead to abnormal protein deposition in the nervous system. This paper presents a detailed and systematic review of recent studies on autophagy and AD.
作者
郭利晴
张慧予
孙晓红
GUO Li-qing;ZHANG Hui-yu;SUN Xiao-hong(The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China)
出处
《解剖科学进展》
2018年第6期660-663,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(3070220)
国家人力资源和社会保障部留学人员科技活动项目择优资助项目(人社函【2015】192号)
