摘要
目的观察疏肝健脾层级疗法(柴胡加龙骨牡蛎汤、归脾汤)对围绝经期失眠症患者睡眠和生活质量的影响。方法采用随机数字表法将围绝经期失眠症患者120例分为观察组和对照组各60例。观察组于治疗初期予柴胡加龙骨牡蛎汤加减,治疗后期予归脾汤加减,每日1剂,水煎服;对照组予艾司唑仑片,每次2片,睡前30 min口服。2组均连续治疗3个月。观察2组治疗前后简明健康调查量表(SF-36)、匹兹堡睡眠质量指数量表(PSQI)评分,雌二醇(E2)、促卵泡激素(FSH)水平及不良反应。结果观察组治疗后SF-36中精力、社会功能、情感职能、生理职能、精神健康、一般健康状态明显改善(P<0.05,P<0.01);对照组精力、社会功能、精神健康明显改善(P<0.05)。与本组治疗前比较,2组PSQI总分明显降低(P<0.05,P<0.01);2组治疗后比较,观察组PSQI总分明显低于对照组(P<0.05)。与本组治疗前比较,观察组E2水平明显改善(P<0.05)。2组治疗后比较,观察组E2水平明显高于对照组(P<0.05)。2组不良反应比较差异有统计学意义(P<0.05)。结论疏肝健脾层级疗法可有效改善围绝经期失眠症患者的生活质量和睡眠质量,改善雌激素水平,且不良反应较小。
Objective To investigate the effects of Shugan Jianpi Multi-level Therapy (Chaihujia Longgu Muli Decoction and Guipi Decoction)on quality of sleep and life in patients with insomnia in perimenopause. Methods Totally 120 outpatients with insomnia during perimenopausal period were divided into observation group and control group through random number table method,with 60 cases in each group.The patients in the observation group were treated with Chaihu jia Longgu Muli Decoction and modified Guipi Decoction,one dosage per day, decoction;Patients in the control group took estazolam tablets,twice a day,orally taken 30 min before sleep.The treatment for both groups lasted for three months.The results of short form 36 guestionnaire (SF-36),Pittsburgh sleep quality index (PSQI),estradiol (E2),follicle stimulating hormone (FSH),and adverse reactions in both groups were observed.Results The vitality,social function,role of emotion,physical function,mental health and general health status of SF-36 in the observation group were significantly improved after treatment (P<0.05,P<0.01);The vitality, social function and mental health of the control group were significantly improved (P<0.05).Compared with before treatment,the total scores of PSQI in the two groups were significantly lowered (P<0.05,P<0.01).The total score of PSQI in the observation group was significantly lower than those in the control group (P<0.05).Compared with before treatment,E2 level of the observation group was significantly improved (P<0.05).Alter treatment,EE level inthe observation group was significantly higher than that in the control group (P<0.05).There was statistical significance in the adverse reactions between the two groups (P<0.05).Conclusion Shugan Jianpi Multi-level Therapy can effectively improve quality of sleep and life in patients with insomnia in perimenopause and estrogen levels with less adverse reactions.
作者
陈英群
李桃桃
陈忆
林亦鑫
CHEN Yingqun;LI Taotao;CHEN Yi;LIN Yixin(Yangpu Hospital,Tongii University,Shanghai 200090,China;Institute of Traditional Chinese Medicine,Tongji University,Shanghai 200092,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2019年第1期18-22,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
上海市卫计委立项课题(201440334)
关键词
柴胡加龙骨牡蛎汤
归脾汤
围绝经期
失眠症
生活质量
Chaihujia Longgu Muli Decoction
Guipi Decoction
perimenopause
insomnia
life quality
