摘要
目的:研究子宫内膜样腺癌微囊性、伸长及碎片状(MELF)浸润模式患者的临床病理特征及其在子宫内膜样腺癌患者中的预后价值。方法:回顾性收集179例子宫内膜样腺癌患者的临床及病理资料。由两名高年资且经验丰富的病理医生对所有病例的病理切片进行重新阅片。通过单因素分析研究子宫内膜样腺癌MELF浸润模式的临床病理特征;采用Kaplan-Meier法绘制生存曲线;采用Cox风险比例模型进行预后相关的多因素分析。结果:MELF浸润模式的发生率为15. 6%(28/179)。MELF浸润模式在低级别的子宫内膜样腺癌中发生率较高级别高(19. 3%与2. 6%,P <0. 05)。MELF浸润模式与FIGO分期较高、子宫颈间质受累、淋巴脉管间隙浸润、肌层浸润≥1/2、淋巴结转移有关(P<0. 05)。有MELF浸润模式的宫内膜样腺癌患者与无MELF浸润模式的患者相比,总生存率和无复发生存率差异均无统计学意义(P>0. 05)。结论:MELF浸润模式与宫内膜样腺癌FIGO分期高、子宫颈间质受累、淋巴脉管间隙浸润、肌层浸润≥1/2、淋巴结转移等不良临床病理因素相关。MELF浸润模式对子宫内膜样腺癌的患者预后影响不大。
Objective: To investigate the clinical pathological features of Microcystic,Elongated and Fragmented( MELF) pattern and its prognostic value in patients with endometrioid adenocarcinoma.Methods: The clinical and pathological data of 179 patients with endometrioid adenocarcinoma were retrospectively collected in Dalian City Maternity Hospital Affiliated to Dalian Medical University.All archival pathological sections were reviewed by two senior and experienced pathologists.The clinical pathological features of MELF pattern was analysed by univariate analysis study,survival curves was draw by Kaplan-Meier method,prognosis-related multivariate analysis by Cox proportional hazards model. Results: The rate of MELF pattern in endometrioid adenocarcinoma was15. 6%( 28/179). MELF pattern had a high incidence in low-grade endometrioid adenocarcinoma( 19. 3% and2. 6%,P<0. 05).There was a significant correlation between MELF pattern and the advanced FIGO stage,LVSI,the depth of myometrial invasion,cervical stroma involvement,the lymph node metastasis( P <0. 05).There was no statistical difference in OS and RFS between patients with MELF pattern and those without MELF pattern.Conclusions: The MELF pattern is associated with histologic findings,such as advanced FIGO stage,larger tumor size,LVSI,myometrial invasion of more than 1/2,and lymph node metastasis.MELF pattern has little effect on the prognosis of patients withendometrioid adenocarcinoma.
作者
韩虹宇
姜继勇
HAN Hongyu;JIANG Jiyong(Dalian Obstetrics and Gynecology Hospital Affiliated to Dalian Medical University Dalian City Maternity Hospital 0Gynecological Tumor Diagnosis and Treatment Center,Dalian Liaoning 116033,China)
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2019年第1期54-59,共6页
Journal of Practical Obstetrics and Gynecology
关键词
子宫内膜样腺癌
微囊性
伸长及碎片状浸润模式
预后
Endometrial endometrioid carcinoma
Microcystic elongated and fragmented pattern
Prognosis
