摘要
目的探讨动脉介入化疗在软组织肉瘤(soft tissue sarcomas, STS)综合治疗中的疗效和影响因素。方法回顾性分析2012年1月至2017年10月在解放军第307医院接受介入化疗的103例STS患者的临床资料,其中动脉单纯灌注化疗30例和介入栓塞联合灌注化疗73例。观察介入治疗的不良反应,不同病理分级、动脉泵入时间、是否联合栓塞的组间疗效差异,以及患者的生存情况。结果 103例患者中,15例行1次介入化疗,35例行2次,35例行3次,18例行4次;最常见的不良反应为恶心呕吐,发生率为42.7%,均为Ⅰ、Ⅱ级,未出现严重不良反应;总有效率为87.4%,中位生存期16.9个月,1年和2年生存率分别为63.6%和33.3%,中位无进展生存期为3.4个月;病理分级G1+G2组疗效明显优于G3组(P<0.001),动脉泵入时间2 h与4 h、单纯化疗组与化疗栓塞组之间疗效差异无统计学意义(P>0.05)。结论介入灌注化疗栓塞治疗安全性较好,能有效控制肿瘤,已成为STS综合治疗的重要手段之一。
Objective To explore the efficacy and influencing factors of arterial interventional chemotherapy embolization in the combined treatment of soft tissue sarcoma(STS). Methods The clinical data and interventional chemotherapy of 103 patients with soft tissue sarcoma diagnosed in The 307 th Hospital of PLA from January 2012 to October 2017 were retrospectively analyzed. Thirty cases were in the arterial perfusion chemotherapy group, 73 cases were in the interventional embolization and perfusion chemotherapy group. Efficacy of interventional therapy were observed, the effect of different pathological grades, arterial pumping time of 2 h and 4 h, whether combined with embolization, and survival data were observed. Results Among the 103 patients, 15 patients received interventional chemotherapy one time, 35 received two times, 35 received three times and 18 received four times. The most common adverse reactions were nausea and vomiting(incidence of 42.7%,Ⅰ, Ⅱ level), no serious adverse reactions appeared. Total effective rate was 87.4%, median survival was 16.9 months, 1-year survival rate and 2-year survival was 63.6% and 33.3%, and median progression-free survival period was 3.4 months. The efficacy rate of the G1+G2 group was significantly higher than that of the G3 group(P <0.001). There was no significant difference in efficacy between the arterial pumping time at 2 h and 4 h, and between the simple chemotherapy group and the chemotherapy embolization group(P < 0.001). Conclusions Interventional perfusion chemotherapy embolization for STS is safe and effective in tumor control.
作者
李静
祝宝让
刁立岩
杨武威
Li Jing;Zhu Baorang;Diao Liyan;Yang Wuwei(Department of Oncology Minimally Invasive,The 307 th Hospital of PLA,Beijing 100071,China)
出处
《北京医学》
CAS
2018年第12期1114-1117,共4页
Beijing Medical Journal
关键词
软组织肉瘤
动脉化疗
介入栓塞
soft tissue sarcoma (STS)
arterial chemotherapy
interventional embolization
