清远地区ANCA相关性血管炎61例临床分析被引量：1

Clinical manifestations in 61 patients with anti-neutrophil cytoplasmic autoanfibodies related vasculitis in Qingyuan area

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摘要目的分析清远地区抗中性粒细胞胞浆抗体(ANCA)相关性血管炎患者多系统受累的临床表现。方法回顾性分析2002年1月至2017年6月清远市人民医院肾内科确诊为ANCA相关性血管炎的61例患者的临床资料。结果胞浆型ANCA (cANCA)阳性5例,核周型ANCA (pANCA)阳性48例,抗髓过氧化物酶抗体(MPOAb)阳性51例,抗蛋白酶3抗体(PR3-Ab)阳性10例;其中cANCA合并PR3-Ab阳性2例,pANCA合并MPO-Ab阳性42例;pANCA合并PR3-Ab阳性6例(其中合并抗核抗体阳性4例),cANCA合并MPO-Ab阳性3例(其中合并抗核抗体阳性1例)。该病临床表现复杂多样,目前主要采用激素联合免疫抑制剂方案治疗,但患者接受程度及依从性较差,大部分已进入肾衰竭期并行肾脏替代治疗。结论 ANCA相关性血管炎在清远地区并非不常见,临床上表现为多系统受累患者,需警惕ANCA相关性血管炎可能,推广ANCA检测有助于提高早期诊断率。 Objective To analyze the clinical manifestations of multi-system involvement in 61 patients with anti-neutrophil cytoplasmic autoanfibodies(ANCA) related vasculitis in Qingyuan area. Methods The clinical datas of61 patients with ANCA related vasculitis diagnosed in Department of Nephropathy, Qingyuan People’s Hospital from January 2002 to June 2017 were retrospectively analyzed. Results There were 5 cases of cytoplasmic ANCA(cANCA)positive, 48 cases of perinuclear ANCA(pANCA) positive, 51 cases of anti-myeloperoxidase antibodies(MPO-Ab) positive, 10 cases of anti-proteinase 3 antibody(PR3-Ab) positive, among which there were 2 cases positive for both c ANCA and PR3-Ab, 42 cases positive for both pANCA and MPO-Ab, 6 cases positive for both pANCA and PR3-Ab(of which 4 cases were positive for antinuclear antibody), 3 cases positive for cANCA combined with MPO-Ab(of which 1case was positive for antinuclear antibody). The clinical manifestations of the disease are complex. Currently the main treatment for the disease is glucocorticoid and immunosuppressive medicine, but the patients’ acceptance and compliance are poor. Most of the patients have entered the stage of renal failure and have been treated with renal replacement therapy. Conclusion ANCA related vasculitis is common in Qingyuan area, and its clinical manifestation is multi-system involvement. It is necessary to be alert to the possibility of ANCA related vasculitis, and popularizing ANCA detection is helpful to improve the early diagnosis rate.

作者尚榆淇魏建波卢勤燕吴传聪彭翔 SHANG Yu-qi;WEI Jian-bo;LU Qin-yan;WU Chuan-cong;PENG Xiang(Department of Nephropathy, the Sixth Affiliated Hospital of Guangzhou Medical University (Qingyuan People's Hospital),Qingyuan 511518,Guangdong, CHINA)

机构地区广州医科大学附属第六医院清远市人民医院肾内科

出处《海南医学》 CAS 2019年第1期41-44,共4页 Hainan Medical Journal

基金广东省清远市人民医院创新研究基金(编号:1014021)

关键词清远地区抗中性粒细胞胞浆抗体血管炎临床分析 Qingyuan area Anti-neutrophil cytoplasmic autoantibodies (ANCA) Vasculitis Clinical analysis

分类号 R543 [医药卫生—心血管疾病]

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