摘要
目的探讨纳络酮治疗急性重型颅脑损伤的疗效及其对患者血浆内皮素(ET)含量的影响。方法选择2016年1月至2017年10月期间解放军第174医院急诊医学科收治的64例急性重型颅脑损伤患者为研究对象,根据随机数表法分为观察组与对照组,每组32例,对照组予脱水降颅压等常规治疗,观察组联合应用纳洛酮治疗,疗程为14 d,比较两组患者治疗前及治疗3 d后血浆ET水平的变化;比较两组患者清醒时间及治疗后日常生活能力(ADL)、神经功能缺损程度评分(NIHSS)水平。结果治疗3 d后,观察组患者的血浆ET水平为(76.4±15.3) pg/mL,明显低于对照组的(95.2±17.1) pg/mL,差异均有统计学意义(P<0.05);治疗后,观察组患者的苏醒时间为(12.3±2.3) d,明显短于对照组的(16.4±3.1) d,且观察组ADL评分为(68.4±10.2)分,NIHSS评分为(9.2±1.8)分,与对照组的(56.6±9.4)分、(11.0±2.2)分比较,差异均有统计学意义(P<0.05)。结论纳洛酮治疗急性重型颅脑损伤有利于患者血浆内皮素水平的降低,明显促进颅脑损伤患者神经功能的恢复,提高日常生活能力。
Objective To investigate the effect of naloxone in the treatment of acute severe craniocerebral injury and its effect on the plasma endothelin(ET) content. Methods During January 2016 and October 2017, 64 patients with acute severe craniocerebral injury in Department of Emergency Medicine, 174 thHospital of Chinese PLA were selected and divided into observation group and control group according to random number table, with 32 patients in each group. The control group was treated with dehydration for reducing intracranial pressure and other conventional treatment, while the observation group used naloxone additionally, for 14 days. The change of plasma ET in the two groups was compared before treatment and 3 days after treatment, as well as recovery time after treatment, and Activity of Daily Living(ADL) Scale, and the National Institutes of Health Stroke Scale(NIHSS) score. Results At 3 days after treatment, plasma ET in observation group was(76.4±15.3) pg/mL, significantly lower than(95.2±17.1) pg/mL in the control group(P<0.05). After treatment, the recovery time in observation group was(12.3 ± 2.3) d, significantly shorter than(16.4±3.1) d in the control group, and the ADL score and NIHSS score of observation group was(68.4±10.2),(9.2±1.8),as compared with(56.6±9.4),(11.0±2.2) in the control group(P<0.05). Conclusion Naloxone in the treatment of acute severe craniocerebral injury is conducive to the reduction of plasma ET, which can significantly improve the recovery of neurological function and daily life ability.
作者
朱海
龙平
赖日华
ZHU Hai;LONG Ping;LAI Ri-hua(Department of Emergency Medicine,174th Hospital of Chinese PLA,Xiamen 361000,Fujian,CHINA)
出处
《海南医学》
CAS
2019年第1期73-75,共3页
Hainan Medical Journal
关键词
急性重型颅脑损伤
纳洛酮
内皮素
疗效
Acute severe craniocerebral injury
Naloxone,Endothelin
Curative effect
