摘要
环状RNA是一类非编码RNA,其首尾两端共价闭合呈环状,表现出与线性RNA不同的特点。大量研究结果显示,环状RNA在原发性肝癌的发生、发展中发挥了重要的作用。现结合国内外在该领域的最新研究进展,概述环状RNA在肝癌中的异常表达情况及其调控肝癌发生、发展中的机制,分析其作为肝癌分子标志物的重要依据,分析环状RNA在肝癌诊治中的潜在价值。
Circular RNA is a class of non-coding RNAs, which are covalently closed and circular at both ends, showing dissimilar characteristics from linear RNA. Several studies have shown that circular RNAs play an important role in the occurrence and development of primary hepatic cancer. By combining with the latest research progress of this field at home and abroad, we summarized the mechanism regulating the occurrence and development of liver cancer, abnormal expression, and as potential molecular markers for disease diagnosis and treatment.
作者
蒋镇洛
沈丽丽
胡耀仁
郭俊明
付丽云
Jiang Zhenluo;Shen Lili;Hu Yaoren;Guo Junming;Fu Liyun(Department of Biochemistry and Molecular Biology,Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University,Ningbo 315211,China;Department of Hepatology,Ningbo No.2 Hospital Ningbo 315020,China;Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province,Ningbo 315020,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2019年第2期157-160,共4页
Chinese Journal of Hepatology
基金
浙江省自然科学基金(LQ19H160007)
浙江省公益技术应用研究计划项目(LGF19H160012)
浙江省医药卫生科技项目(2017KY140,2018RC062)
宁波市社发重大项目(2016C51005)
宁波大学王宽诚基金.
