摘要
该文宗旨为中医药治疗痛风病的研究提供可靠的实验方法。基于痛风病的临床病症特点,分析目前常用的痛风动物模型,探讨现有痛风动物模型与临床病症的吻合情况及应用前景。目前对痛风的研究主要采用高尿酸血症模型、痛风性急性关节炎模型、痛风性肾病模型3类模型方法,痛风病的造模方法较多,但缺少能反映痛风病临床病症特点、体现痛风病中医病因的动物模型复制,与临床病症仍存在一定差距。该文总结了高尿酸血症模型、痛风性急性关节炎模型、痛风性肾病模型3类模型的特点及造模方法,比对临床相关症状及标准,对现有动物模型与临床病症的吻合情况进行分析探讨,进而提出相应动物模型的评价及改进方法。
According to the characteristics of gout’s clinical symptoms,the common gout animal models were analyzed,and the anastomosis and application prospect of the existing gout animal models with the clinical symptoms were discussed. At present,there are three models of gout: hyperuricemia model,gouty arthritis model and gouty nephropathy model. There are many methods of gout modeling,but there is a lack of animal model replication that could reflect the characteristics of gout’s clinical symptoms and reflect the etiology of gout,and there is still a gap between the clinical symptoms and the clinical symptoms. In this paper,the characteristics and modeling methods of the three animal models were summarized,and compared with the clinical symptoms and standards,the anastomosis between the existing animal models and the clinical symptoms were analyzed and discussed,and the evaluation and improvement methods of the corresponding animal models were put forward. It provides a reliable experimental method for the treatment of gout by traditional Chinese medicine.
作者
康乐
苗明三
刘慧娟
李宁
KANG Le;MIAO Ming-san;LIU Hui-juan;LINing(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第22期4547-4552,共6页
China Journal of Chinese Materia Medica
基金
国家国际合作基地项目(2016-151)
中原学者项目(162101510003)
