摘要
内源性毒性成分已经成为中药领域研究中的重要话题。其中,中药内源性毒性成分往往作为临床上有效成分来使用,因此保证内源性毒性物质的安全性和有效性已经成为中药研究的重要部分。该文阐述了毒性中药材的分级及评判标准,结合色谱法、光谱法、免疫分析法等技术对中药中内源性化学成分的分析方法进行了总结和阐述,并在此基础上对内源性毒性成分分析中存在的问题进行了讨论,为含内源性有毒成分中药材的有效性和安全性评价提供思路和方法。
Endogenous toxic components have become an important topic in the field of traditional Chinese medicines( TCMs).Since the endogenous toxic components in TCMs are often used as clinical effective components,the safety and effectiveness of endogenous toxic substances has become an important part of the research of TCMs. In this paper,the classification and evaluation criteria of toxic Chinese medicinal materials are described,and the analytical methods of endogenous components in TCMs are summarized and expounded base on with the techniques of chromatography,spectroscopy,immunoassay,and so on. On this basis,the problems in terms of endogenous toxic components are analyzed and discussed. This paper could provide ideas and methods for the evaluation of the validity and safety of TCMs containing endogenous toxic components.
作者
段亚萍
骆骄阳
刘好
单利楠
杨世海
杨美华
DUAN Ya-ping;LUO Jiao-yang;LIU Hao;SHAN Li-nan;YANG Shi-hai;YANG Mei-hua(Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Peking Union Medical College, Belting 100193,China;College of Traditional Chinese Medicine,Jilin Agricultural University,Changchun 130118,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第24期4808-4816,共9页
China Journal of Chinese Materia Medica
基金
中国医学科学院医学与健康科技创新工程(2017-I2M-1-013,2016-I2M-3-010)
关键词
中药
内源性毒性成分
分级
评判标准
分析方法
traditional Chinese medicine
endogenous toxic components
grading
evaluation criteria
analytic methods
