摘要
该研究基于Meta分析类文献分析5种中药注射剂治疗心力衰竭的临床使用特点。共纳入24篇Meta分析类文献,涉及参附注射液、参麦注射液、生脉注射液、丹红注射液、黄芪注射液5个注射剂品种,其中参附注射液、参麦注射液和生脉注射液文献数量较多,以上注射剂联合西药常规治疗较西药单独治疗有效率显著提高、对6 min步行实验、射血分数、脑肽钠等指标显著改善。参附注射液还可以改善患者生存质量、调节心率等指标。参附注射液可用于偏阳虚证患者,参麦注射液可用于偏阴虚患者,生脉注射液可用于气阴两虚证患者。可见西医常规治疗联合中药注射剂治疗心衰可以提高疗效,其中参附注射液、参麦注射液、生脉注射液临床使用较多,临床使用时需要对症治疗。目前中药注射剂的临床研究文献水平较低,对于药物的有效性、安全性评价仍需高水平的临床证据。
In this article,we analyze the clinical characteristics of five kinds of traditional Chinese medicine injections in treating heart failure based on Meta-analysis. A total of 24 Meta-analysis papers were included,which involved Shenfu Injection,Shenmai Injection,Shengmai Injection,Danhong Injection and Huangqi Injection. The numbers of literatures of Shenfu Injection,Shenmai Injection and Shengmai Injection are high than the other two injections. The efficiencies of these injections combined with Western medicine are higher than the Western medicine used alone. They can improve 6 minute walk test result,ejection fraction,the level of brain peptide sodium and so on. Shenfu Injection can also improve the living quality of patients’ life,heart rate and other indicators. Shenfu Injection can be used for patients with Yin deficiency,while Shenmai Injection can be used for patients with Yin deficiency and Shengmai Injection can be used for patients with Qi and Yin deficiency. From this information,we can see that Western medicine combined with traditional Chinese medicine injections can significantly improve the clinical efficiency. These injections need to be used according to patients’ symptom. In the present,as the quality of clinical research literature of traditional Chinese medicine injections is low,the efficiency and safety evaluation of Chinese medicine injections still requires higher level of clinical evidence.
作者
柏冬
岳广欣
王瑞海
苗青
许京
刘丽梅
BAI Dong;YUE Guang-xin;WANG Rui-hai;MIA0 Qing;XU Jing;LIU Li-mei(Institute of Basic Theory of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beifing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第20期4152-4162,共11页
China Journal of Chinese Materia Medica
基金
国家重点基础研究发展计划(973)项目(2012CB518401)
关键词
心力衰竭
中药注射剂
临床疗效
META分析
heart failure
Chinese medicine injection
clinical efficiency
Meta-analysis
