摘要
目的:采用不同化学处理方法对PEEK材料进行表面改性,提高PEEK材料的生物性能。方法:根据不同的化学处理方法分为5组(n=9):①空白对照组(PEEK):PEEK材料表面机械抛光,不进行酸处理;②浓硫酸处理5 min组(S1-PEEK);③浓硫酸处理10 min组(S2-PEEK);④浓硫酸处理5 min后,硝酸处理5 min(S+n-PEEK);⑤高锰酸钾+磷酸处理PEEK(Mn-PEEK);处理后五组材料在100℃水浴加热4 h。FE-SEM观察样本表面形貌,XPS检测样本化学组成,SEM观察细胞在材料表面的状态。结果:①组样本表面光滑,②、③、④组样本表面可见3D筛状孔结构,⑤组样本表面形成花瓣样结构。①、②、③、④、⑤中硫元素的质量百分比分别为:0、2. 45±0. 22、3. 48±0. 16(与②组比较,P=0. 000)、1. 79±0. 05(与②组比较,P=0. 002)和0。各试验材料表面培养的BMSCs细胞及伪足数量均多于对照组。结论:酸蚀PEEK材料可增加其表面生物性能;水浴可去除材料表面残余酸,进一步提高PEEK材料表面的生物性能。
Objective: To improve the bioactivity of PEEK by chemical methods. Methods: PEEK samples were treated by polish only( group(1));concentrated sulfuric acid for 5 min( group(2));concentrated sulfuric acid for 10 min( group(3));concentrated sulfuric acid for 5 min,followed by treatment of hydrogen nitrate for 5 min( group(4)) and mineral chameleon and ortho-phosphoric acid( group(5)) respectively( n = 9). Then,all samples were treated by water at 100 ℃ for 4 h. The sample surface was observed by FE-SEM,the chemical comporent of the samples was analyzed by XPS. BMSCs were cultured on the sample surface for 4 h and observed by SEM. Results: The sample sureface in group(1) was smooth,in group(2),(3) and(4) was with 3 D ethmoidal foramen structure,in group(5) with petal-like from. The sulfur content( Wt%) of the samples of group(1),(2),(3),(4) and(5) was 0,2. 45 ± 0. 22,3. 48 ± 0. 16( vs(1),P= 0. 000),1. 79 ± 0. 05( vs(1) P = 0. 002) and 0 respectively. BMSCs cultured on the sample surface of group(2),(3),(4) and(5) were more and with more pseudopod. Conclusion: The bioactivity of PEEK can be enhanced after acid pickling. Water bath and nitric acid treatment can remove the residual acid and further enhance the bioactivity of PEEK.
作者
李艳华
何东
王菁
吴高义
LI Yanhua HE Dong;WANG Jing;WU Gaoyi(Department of Stomatology,Ji'nan Military General Hospital of Jinzhou Medical University,China,250031;Department of Stomatology,Jinan Military General Hospital)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2019年第1期32-36,共5页
Journal of Practical Stomatology
基金
国家自然科学基金面上项目(编号:61471384)
关键词
聚醚醚酮
化学处理
磺化
表面改性
Polyetheretherketone
Chemical treatment
Sulfonated
Surface modification
