摘要
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是女性最常见的内分泌紊乱疾病,影响全球4%~12%育龄期女性的生殖健康,是导致女性发生不孕最常见的因素之一。PCOS病因复杂且发病机制未完全明确,在众多致病因素中,氧化应激(OS)被认为是PCOS发病的因素之一,且与其临床症状的发生及进展有密切关系。循环中异常增高的OS产物还会导致该类患者发生心脑血管疾病、肝病、肿瘤的风险上升,甚至影响子代的健康。因此,OS在PCOS患者病情的进展中起至关重要的作用。本文就OS在PCOS患者相关临床症状中的发病机制做一简要综述。
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, affecting the reproductive health of 4%-12% women with childbearing age worldwide, and is one of the most common factors leading to infertility in women. The etiology of PCOS is complex and the pathogenesis is not completely clear. Among the many pathogenic factors, oxidative stress is considered to be one of the factors in the pathogenesis of PCOS, and it is closely related to the occurrence and progression of clinical symptoms. The abnormally elevated oxidative stress products in the circulation can also lead to an increased risk of cardiovascular and cerebrovascular diseases, liver diseases, and tumors in such patients, and even affect the health of the offspring. Therefore, oxidative stress plays a crucial role in the progression of PCOS patients. This article provides a brief review of the pathogenesis of oxidative stress in clinical symptoms associated with PCOS patients.
作者
刘莹
高雪林
丁媛
张学红
王一青
Liu Ying;Gao Xuelin;Ding Yuan;Zhang Xuehong;Wang Yiqing(The First Hospital of Lanzhou University,Key Laboratory for Reproductive Medicine and Embryo,Lanzhou 730000,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2019年第1期79-82,共4页
Chinese Journal of Reproduction and Contraception
基金
甘肃省杰出青年基金(18JR3RA262)
兰州大学中央高校基本科研业务费专项资金资助(lzujbky-2018-kb23).
关键词
氧化应激
多囊卵巢综合征
心血管疾病
子代
Oxidative stress
Polycystic ovary syndrome
Cardiovascular disease
Offspring
