摘要
目的探讨合肥市手足口病(hand,foot and mouth disease,HFMD)多次感染状况及其流行特征,为其防控提供科学依据。方法整理"传染病报告信息管理系统"中现住址为合肥市的HFMD个案,筛选出多次感染的病例,采用描述性流行病学方法进行分析。结果 2011-2016年合肥市HFMD再感染发病率为10.73/10万,多次感染发生率为5.12%。83.36%的再次感染发生在上一次感染后两年内。单次感染和多次感染首次发病年龄中位数分别为2.30岁和1.94岁,差异有统计学意义(Z=-28.84,P<0.001)。0~岁组儿童多次感染发生率(8.15%)最高,<6岁儿童随着年龄的增长多次感染发生率逐渐下降(X_(趋势)~2=609.28,P<0.001)。男童更容易发生多次感染,再感染病例幼托儿童构成比高。HFMD发病率高的地区再感染发病率也高。结论合肥市HFMD多次感染疫情比较严重,需重点关注首次发病年龄小于3岁的男童、幼托儿童等人群及发病率高的地区,采取有针对性的防控措施。
Objective To explore the multiple infection status of hand,foot and mouth disease( HFMD) and its epidemiological characteristics in Hefei City to provide scientific evidence for HFMD prevention and control. Methods The cases of multiple infection of HFMD living in Hefei were screened out from National Notifiable Disease Report System and analyzed by descriptive epidemiology. Results The incidence of reinfection of HFMD in Hefei from 2011 to 2016 was 10. 73 per 100 000,and the incidence of multiple infections was 5. 12%. 83. 36% of the reinfection occurred within two years of the last infection. The median age of first infection among multiple infections was 1. 94 years old and single infection cases was 2. 30 years old,there was significant difference( Z =-28. 84,P < 0. 001). The incidence of multiple infections in the 0-year-old group was the highest( 8. 15%),and the incidence of multiple infections decreased with age in children less than 6 years old( χtrend2= 609. 28,P < 0. 001). Boys were more susceptible to multiple infections,and reinfection cases were mainly occurred by the children in kindergarten. The incidence of reinfection was also high in areas with high incidence of HFMD. Conclusions Multiple infections of HFMD is a serious common health threat to children in Hefei. We should pay more attention to the population including boys with a first onset age less than three years old,kindergarten children as well as children from areas with high incidence and take prevention and control measures.
作者
尤恩情
陈丽丽
吴金菊
黄芬
YOU En-qing;CHEN Li-li;WU Jin-ju;HUANG Fen(Health Emergency Office,Hefei Center for Disease Control and Prevention,Hefei 230061,China;Department of Epidemiology and Health Statistics, School of Public Health,Medical University of Anhui,Hefei 230032,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2018年第3期266-271,共6页
Chinese Journal of Disease Control & Prevention
关键词
手足口病
感染
发病率
流行病学研究
Hand,foot and mouth disease
Infected
Incidence
Epidemiological study
