摘要
目的 评价联合检测脂肪酶 (Lipase)和白细胞介素 6(IL 6)或Lipase和C 反应蛋白 (CRP)是否能够快速诊断和有效区分急性胰腺炎病情轻重。方法 检测 40名非胰腺炎急腹症病人 ,40名急性胰腺炎病人 (包括 2 5名轻度胰腺炎病人和 15名重症胰腺炎病人 )和 40名健康对照组人员的血清Lipase ,IL 6,CRP水平。结果 Lipase(判定点设在 45 0 μ/L)可以正确区分 97%的急性胰腺炎病人和其它急腹症病人 ,有 2名急性胰腺炎病人Lipase低于 45 0 μ/L而未能正确区分。IL 6(判定点设在 3 7μg/L) ,可以正确区分重症胰腺炎和轻度胰腺炎 ,敏感性为 10 0 % (15 /15 ) ,特异性为 87% (2 0 /2 3 ) ,可以对急性胰腺炎的病情程度进行准确分级。CRP(判定点设在 6mg/L)显示预后效率低于IL 6,敏感性为 87% (13 /15 ) ,特异性为 48% (11/2 3 )。结论 联合检测Lipase和IL 6可以快速诊断急性胰腺炎和有效区分病情轻重 。
Objective To evaluate the usefulness of serum lipase associated with either interleukin 6(IL 6) or c reactive protein (CPR) in rapid diagnosis and efficient prognosis of patients with acute pancreatitis. Method Serum lipase ,IL 6 and CRP in 40 patients with nonpancreatic acute abdomen ,40 patients with acute pancreatitis (including 25 patients with mild acute pancreatitis and 15 patients with severe acute pancreatitis ) and 40 healthy controlled people were detected and compared. Results Serum lipase in all patients but 2 is higher than that in healthy people. IL 6 was a useful marker in assessment of severity of acute pancreatitis ,the sensitivity and specificity were 100% and 87% respectively,moreover ,the sensitivity and specificity of CRP as a marker were 87% and 48% respectively.Conclusion It is useful to detect serum lipase associated with IL 6 in rapid diagnosis and efficient prognosis of patients with acute pancreatitis.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2002年第3期332-333,共2页
Journal of Third Military Medical University
