摘要
为研究益气健脾通络复方的作用 ,采用不规则进食加稀盐酸喂养制作大鼠功能性消化不良 (FD)模型 ,并随机分成A、B、C、D四组 ,分别给予胃祺Ⅱ号方 (主药 :党参、黄芪、莪术、枳壳 )、木香顺气丸、普瑞博思和蒸溜水灌胃 ,2 8d后观察胃排空、检测胃体组织中一氧化氮 (NO)、下丘脑中促甲状腺释放激素 (TRH)含量。结果 :胃排空率A、B、C三组无差异 (P >0 0 5 ) ,但A组胃排空水平恢复均匀平稳 ,接近E组 (正常组 ) ;A组NO、TRH的变化最明显 ,与D组比较有显著差异 (P <0 0 5～ 0 0 1) ,而B、C组与D组之间无明显差异 (P >0 0 5 )。提示胃祺Ⅱ号方对FD有良好的治疗作用 ,能增强胃肠的动力顺应性 。
In order to study the function of thecompound formula to benefit qi,strengthen the spleen and dredge the collaterals,functional indigestion models in rats were made by irregular food intake plus diluted hydrochloric acid and divided randomly into four groups (A,B,C,D) and fed respectively with 'Stomach Peace NO.2 Formula'(main ingredients:Radix Codonopsis Pilosulae,Radix Astragali,Rhizoma Zedoariae,Fructus Aurantii),'Aucklandia Qi Smoothing Pills',Preculsid and distilled water.28 days later,the stomach emptying was observed to determine the contents of nitrous oxide (NO) in the tissues of the gastric antrum and thyrotrophin releasing hormone (TRH) in the hypothalamus.The results showed that there was no difference in the stomach emptying rate in A,B and C groups ( P >0.05),but the restoration of the stomach emptying level in Group A was even and stable,close to the Group E (the normal group);and that change in NO and TRH was most obvious in Group A,with a significant difference in comparison of Group D(P<0.05～0.01),and with no difference in comparison of Group B,C and D( P >0.05).The findings indicate that 'Stomach Peace NO.2 Formula' has a better therapeutic effect for functional indigestion and can intensify the dynamic adaptability of the stomach and intestine and may have a regulatory function in cerebral and intestinal peptide hormone in the hypothalamus.
出处
《上海中医药大学学报》
CAS
2002年第1期50-52,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
关键词
功能性消化不良
动物模型
胃祺Ⅱ号方
胃排空
一氧化氮
促甲状腺释放激素
中医药疗法
Functional indigestion,animal model,'Stomach Peace NO.2 Formula',stomach emptying,nitrous oxide(NO),thyrotrophin releasing hormone(TRH)
