摘要
大量动物实验表明环境雌激素具有生殖和 或发育毒性 ,但其作用机制非常复杂 ,尤其在分子机理方面目前不甚明了。本文从信号通路、基因表达。
It has been shown that numerous natural and synthetic chemicals with estrogenic activities are reproductive or developmental toxic factors in humans or animals by epidemiological investigations and animal experiments. The mechanisms of toxicity, however, are very complicated, especially the molecular mechanisms. This article introduced the current progress on molecular mechanisms of toxicity, which included modulating signaling pathways, interfering gene expression during embryo stage, inducing mutation, etc.
出处
《卫生研究》
CAS
CSCD
北大核心
2002年第2期139-141,共3页
Journal of Hygiene Research
基金
国家自然科学基金重点项目 (No 30 0 30 1 2 0)
关键词
环境雌激素
雌激素样化合物
生殖毒性
发育毒性
分子机理
environmental estrogen, estrogenic chemical, reproductive toxicity, developmental toxicity, molecular mechanism
