摘要
目的 :监测全国 5 1家医院 2 0 0 0年葡萄球菌属临床分离株耐药性 ,以探讨葡萄球菌属临床分离株的耐药性现状。方法∶药敏试验采用纸片扩散法 (K B法 )。结果∶⑴在 2 191株金黄色葡萄球菌 (SAU )中耐甲氧西林的金黄色葡萄球菌 (MR SA) 6 5 2株 ,分离率为 2 9.8% ,36 19株凝固酶阴性葡萄球菌 (CNS)中 ,2 5 95株为甲氧西林耐药的凝固酶阴性葡萄球菌 (MRC NS) ,分离率为 71.7%。⑵MRSA、MRCNS对环丙沙星、红霉素、庆大霉素、复方磺胺甲唑、四环素、氯霉素和克林霉素的耐药率分别为 76 .0 %、91.0 %、72 .0 %、5 5 .0 %、72 .0 %、44 .0 %、74.0 %和 5 5 .2 %、82 .0 %、32 .2 %、77.4%、5 8.8%、45 .1%、5 2 .7% ;⑶甲氧西林敏感的凝固酶阴性葡萄球菌 (MSCNS)对环丙沙星、氯霉素、复方磺胺甲唑和四环素的耐药率较甲氧西林敏感的金黄色葡萄球菌 (MSSA)为高 ,但仍对临床常用抗生素环丙沙星、庆大霉素、氯霉素、克林霉素有较好的敏感性 ,耐药率分别为 2 4.3%、7.5 %、31.3%、2 4.4%。结论∶加强对葡萄球菌耐药性的监测是非常必要的。
Objective: To investigate the antimicrobial resistance of staphylococcal isolates from 51 hospitals in 2000 in China. Methods:Antimicrobial susceptibility test was conducted by disk diffusion technique (K B method). Results:⑴ Resistance rates of MRSA, MRCNS isolates to ciprofloxacin, erythromycin, gentamicin, trimethoprim/sulfamethoxazole, tetracycline , chloramphenicol, and clindamycin were 76.0%, 91.0%, 72.0%, 55.0%, 72.0%, 44.0%, 74.0% and 55.2%, 82.0%, 32.2%, 77.4%, 58.8%, 45.1%, 52.7%, respectively. ⑵ The resistance rates of methicillin sensitive coagulase negative staphylococci (MSCNS) to ciprofloxacin, chloramphenicol, tetracycline and trimethoprim/sulfamethoxazole, were higher than those of methicillin sensitive S aureus (MSSA) MSCNS remains sensitive to most of antimicrobial agents routinely used in clinical practice including ciprofloxacin, gentamicin chloramphenicol and clindamycin, the resistance rates were 24.3%, 7.5%, 31.3%, 24.4%. Conclusions: It is important to monitor the antimicrobial resistance of staphylococcus species.
出处
《中国抗感染化疗杂志》
2002年第1期24-26,共3页
Chinese Journal of Infection and Chemotherapy
