摘要
目的 观察赛莱乐对脑出血的治疗作用及安全性。方法 采用定量胶原酶注入大鼠尾状核建立脑出血模型 ,观察赛莱乐对实验鼠注入胶原酶后血肿容积、神经功能缺失征评分及组织病理变化的影响。脑局部微血管用微血管灌注法观察。结果 赛莱乐治疗 5天可以减轻大鼠神经功能缺失体征 ,即 86 %的大鼠由 级转为 级 ,14 %转为 0级 (P<0 .0 5 ) ,改善脑内血肿周围微循环 ,不引起脑内血肿扩大。结论 赛莱乐对实验性脑出血有一定治疗作用 。
Objective To observe the effect and safety of buflomedil hydrochloride injection to intra cerebral hemorrhage in rats. Methods We established the experimental intracerebral hemorrhage (ICH) model in rats by stereotactic injecting quantitative collagenase into their left caudate nucleuses.The effects of buflomedil hydrochloride injection on hematoma volume,the score of neurological function deficit signs, as well as histopathological changes were observed. Local capillaries were observed by micrangium perfusion.Results 5 days after buflomedil hydrochloride injection might alleviate Wister rats' neurological function deficit signs, 86% rats from Grade Ⅲ to Grade Ⅰ, 14% rats from Grade Ⅲ to Grade 0( P <0.05),it could ameliorate microcirculation around intracerebral hematoma.It didn't enlarge intracerebral hematoma.Conclusion Buflomedil hydrochloride injection has certain treatment effect to experimental intracerebral hemorrhage in rats,but it has no side effect on enhancing bleeding.
出处
《临床神经病学杂志》
CAS
2002年第2期88-90,共3页
Journal of Clinical Neurology
关键词
脑出血
赛莱乐
鼠
治疗
Intracerebral hemorrhage Buflomedil hydrochloride Rat
