摘要
目的：比较重组人表皮生长因子（ｒｈＥＧＦ）凝胶剂和水溶液剂治疗烧伤创面的临床疗效。方法：选择烧伤浅Ⅱ°、深Ⅱ°和新鲜供皮区创面为受试对象，将创面分成Ａ、Ｂ两区，采用随机自身对照试验。试验组用重组人表皮生长因子凝胶治疗，对照组用重组人表皮生长因子水溶液治疗，每日换药一次，观察不同时间内创面动态愈合率及愈合时间。结果：重组人表皮生长因子凝胶治疗的烧伤浅Ⅱ°、深Ⅱ°和新鲜供皮区创面其愈合时间较重组人表皮生长因子水溶液组有明显缩短（Ｐ＜０．０１）；动态愈合率也明显加快，组间具有非常显著性差异。结论：重组人表皮生长因子凝胶剂用干烧烫伤、新鲜供皮区创面的治疗均有较好的促进修复作用，临床效果优于重组人表皮生长因子水溶液剂组，提示重组人表皮生长因子的剂型是影响临床效果的重要因素，重组人表皮生长因子的药理作用因剂型的不同而存在差异。
OBJECTIVE: To compare the clinical efficacy of recombinant human epidermal growth factor (rhEGF)gel with solution in treatment of burn wounds. METHODS: The patients suffering from shallow Ⅱ° burn wounds, deep Ⅱ° burn wounds and fresh skin-offering wounds were subjected to the randomized auto- control trials. Each wound was divided into two parts, and the application of the drugs was random. rhEGF gel was used in trial group and rhEGF solution in control group. Dressing change once each day. The dynamic healing rate in different time and healing time were observed. RESULTS: The healing time of all above-mentioned wounds was significantly shorter in rhEGF gel group than the controls (P<O.Ol); The dynamic healing rates were obviously increased, and they are significantly different in groups. CONCLUSION: rhEGF gel can promote the healing in burn wounds, fresh skin-offering wounds, granulation wounds, and its efficacy was better than rhEGF solution. It suggests that the form of drug rhEGF is an important factor in clinical efficacy. The phannacological action of rhEGF varies according to its form of drug.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2002年第1期12-14,共3页
The Chinese Journal of Clinical Pharmacology
关键词
重组人表皮生长因子
凝胶剂
水溶液剂
烧伤
创面愈合
recombinant human epidermal growth factor (rhEGF)
gel
solution
burn wounds, wounds healing
