摘要
兔76只,于下丘脑室旁核(PVH)区注射TRH 2μg/μl,使呼吸频率(RF)、每分通气量(V_E)增加,血压升高(P均<0.01)。于PVH区预注射哌唑嗪(PA)1μg(1μl),使TRH的呼吸兴奋效应减弱,并逆转其升压效应(P<0.01),于双侧侧脑室预注射精氨酸加压素抗血清5μl(效价1:100000),可完全拮抗TRH在PVH区的升压作用(P<0.01),提示TRH在FVH区具有使RF加快V_E增加和升压作用,部分由局部α_1受体介导的;脑内AVP系统可能也参与TRH的升压作用。
The experiment was done in 76 spontaneous-respiration rabbits anesthetized with urethane. After microinjection of TRH into the PVH area, the animals were observed for changes in RF, VE , BP and HR. Followinginjection of 2 μg/μl TRH, significant increase in RF(38.95±9.6%), VE (32.47±12.5%) and BP(16.61±3.4%) was noted. After pretreatment with PA (1 μg/μ1), the effect of TRH was attenuated. Preinjection of A-AVP into the lateral cerebral ventricular, reversed the action of TRH on BP From the foregoing it may be suggested that the effect of TRH is mediated by alpha 1, and that the AVP system plays a role in the hypertensive effect of TRH.
出处
《同济医科大学学报》
CSCD
北大核心
1991年第5期313-315,共3页
Acta Universitatis Medicinae Tongji
关键词
下丘脑
室旁核
TRH
呼吸
血压
paraventricular nucleus
thyrotropin releasing hormone
respiration
blood pressure
