摘要
本文对胰岛素抵抗 (insulinresistance,IR)的机理研究进展作一简单概述 ,据此阐明针刺具有改善胰岛素抵抗的作用 ,并就针刺干预胰岛素抵抗的可能作用靶点提出构想 ,认为在受体前、受体及受体后水平来研究针刺改善胰岛素抵抗 ,最有可能揭示其作用机理 。
In the present study, the authors review some advances of the research on insulin resistance (IR) and the possible action target sites of acupuncture in relieving IR related diabetes, hypertension, adiposis, etc. Findings show that pre receptor and post receptor factors may be responsible for the occurrence of IR. Pre receptor factors generally include ① Insulin (Ins) gene mutation; ② formation of endogenous and exogenous Ins antigens, ③ Ins receptor antigen formation, ④ acceleration of Ins degradation, and ⑤ excessive Ins resisting hormones including glucocorticoid hormone, catecholamine, glucagon, free fatty acid, etc. The post receptor factors mainly contain ① receptor biosynthesis rate lowering induced reduction of receptor count, ② abnormal process of receptor inserting into cellular membrane, ③ reduction of receptor affinity with Ins, ④ acceleration of receptor degradation, and disturbance of receptor re utilization. The possible acupuncture target sites for bettering IR are ① lowering serum Ins level, ② raising C peptide/Ins, ③ increasing Ins resisting hormone content, and ④ elevating Ins sensitivity. The authors also put forward some suggestions about the research on mechanisms of acupuncture in relieving IR from pre receptor, receptor and post receptor levels.
出处
《针刺研究》
CAS
CSCD
2002年第1期73-75,共3页
Acupuncture Research
